78178-28-6

Upstream product

• 518-55-8 conidendrin 
• 71772-18-4 α-conidendrin dimethyl ether 
• 347359-71-1 (7RS,8R,8'R)-4,4',7-trihydroxy-3,3'-dimethoxylignano-9,9'-lactone 
• 21966-92-7 isolariciresinol dimethyl ether 
• 25925-39-7 (3aR)-6,7-dimethoxy-4c-(3,4-dimethoxy-phenyl)-(3ar,9at)-3a,4,9,9a-tetrahydro-3H-naphtho[2,3-c]furan-1-one 

Downstream Products

• 78215-86-8 α-conidendreic acid anhydride dimethyl ether 
• 78178-29-7 α-conidendreic acid dimethyl ester dimethyl ether 
• 1422430-59-8 C₄₀H₃₈O₆ 
• 1422430-67-8 C₄₀H₃₈O₅ 
• 1428415-59-1 C₄₀H₃₆O₅ 
• 42298-60-2 dimethyl 1-(3,4-dimethoxyphenyl)-6,7-dimethoxynaphthalene-2,3-dicarboxylate 

Relevant academic research and scientific papers

Synthesis and structural analysis of sterically hindered chiral 1,4-diol ligands derived from the lignan hydroxymatairesinol

The readily available natural lignan hydroxymatairesinol was transformed into sterically hindered and optically pure diphenyl, di-2-naphthyl, and tetramethyl 1,4-diol derivatives via arylation/alkylation of the aryltetralinbutyrolactone lignan (-)-conidendrin. In addition, the diastereoselective formation of stable hemiketals from the highly substituted butyrolactone was studied in detail. The conformations of the molecules prepared were studied computationally at molecular mechanics (MM), Hartree-Fock (HF)/6-31G*, and (DFT/B3LYP/TZVP) levels including entropy contributions and by NMR-spectroscopy. The conformations adopted showed that these novel chiral 1,4-diols may be suitable as chiral ligands for the development of new chiral transition metal and organo catalysts.