α-conidendreic acid dimethyl ether

Base Information

• Chemical Name: α-conidendreic acid dimethyl ether
• CAS No.: 78178-28-6
• Molecular Formula: C₂₂H₂₄O₈
• Molecular Weight: 416.428
• Mol file: 78178-28-6.mol

Synonyms:α-conidendreic acid dimethyl ether

Chemical Property of α-conidendreic acid dimethyl ether

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of α-conidendreic acid dimethyl ether

There total 6 articles about α-conidendreic acid dimethyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

α-conidendrin dimethyl ether (71772-18-4) → α-conidendreic acid dimethyl ether (78178-28-6)

Guidance literature:

With bromine; sodium hydroxide; In water; at 60 ℃; for 3.5h;

DOI:10.1016/j.tetlet.2012.12.066

Reference yield:

(3aR)-6,7-dimethoxy-4c-(3,4-dimethoxy-phenyl)-(3ar,9at)-3a,4,9,9a-tetrahydro-3H-naphtho[2,3-c]furan-1-one (25925-39-7) → carbon tetrabromide (558-13-4) + 2-(3,4-Dimethoxy-benzoyl)-4,5-dimethoxy-benzoic acid (7249-36-7) + (1S)-1r-(3,4-dimethoxy-phenyl)-6,7-dimethoxy-1,2,3,4-tetrahydro-naphthalene-2t,3c-dicarboxylic acid (26817-99-2,59527-53-6,78178-28-6,78178-51-5) + oxalic acid (144-62-7,97993-78-7)

Guidance literature:

Reference yield:

(7RS,8R,8'R)-4,4',7-trihydroxy-3,3'-dimethoxylignano-9,9'-lactone (347359-71-1) → α-conidendreic acid dimethyl ether (78178-28-6)

Guidance literature:

Multi-step reaction with 3 steps

1: formic acid / 0.16 h

2: potassium carbonate / N,N-dimethyl-formamide / 20 h / 20 °C

3: sodium hydroxide; bromine / water / 3.5 h / 60 °C

With formic acid; bromine; potassium carbonate; sodium hydroxide; In water; N,N-dimethyl-formamide;

DOI:10.1016/j.tetlet.2012.12.066

upstream raw materials:

(3aR)-6,7-dimethoxy-4c-(3,4-dimethoxy-phenyl)-(3ar,9at)-3a,4,9,9a-tetrahydro-3H-naphtho[2,3-c]furan-1-one

isolariciresinol dimethyl ether

(7RS,8R,8'R)-4,4',7-trihydroxy-3,3'-dimethoxylignano-9,9'-lactone

α-conidendrin dimethyl ether

Downstream raw materials:

α-conidendreic acid dimethyl ester dimethyl ether

C₄₀H₃₈O₆

C₄₀H₃₈O₅

C₄₀H₃₆O₅