78178-63-9

Upstream product

• 78178-62-8 ethyl 2-(3,4-dibenzyloxybenzoyl)acetoacetate 
• 1486-54-0 3,4-dibenzyloxybenzoyl chloride 
• 100-39-0 benzyl bromide 
• 1197-09-7 1-(3,4-dihydroxyphenyl)ethan-1-one 
• 27628-06-4 1-(3,4-bis(benzyloxy)phenyl)ethan-1-one 
• 105-58-8 Diethyl carbonate 

Downstream Products

• 78178-85-5 C₂₀H₂₁NO₄*ClH 
• 78178-86-6 4-[6-(3-Hydroxy-4-methoxy-phenyl)-1,2,3,5,8,8a-hexahydro-indolizin-7-yl]-benzene-1,2-diol; hydrochloride 
• 78178-80-0 2-(3-Benzyloxy-4-methoxy-phenyl)-1-{2-[2-(3,4-bis-benzyloxy-phenyl)-2-oxo-ethyl]-pyrrolidin-1-yl}-ethanone 
• 78178-90-2 6-(3-Benzyloxy-4-methoxy-phenyl)-7-(3,4-bis-benzyloxy-phenyl)-1,2,3,5,8,8a-hexahydro-indolizine 
• 78178-83-3 6-(3-Benzyloxy-4-methoxy-phenyl)-7-(3,4-bis-benzyloxy-phenyl)-2,3,8,8a-tetrahydro-1H-indolizin-5-one 
• 78178-88-8 6,7-di(3,4-dibenzyloxyphenyl)-1,2,3,5,8,8a-hexahydroindolizine 
• 78178-81-1 6,7-di-(3',4'-dibenzyloxyphenyl)-5-oxo-1,2,3,5,8,8a-hexahydroindolizine 
• 78178-78-6 2-(3',4'-dibenzyloxyphenacyl)-N-(3'',4''-dibenzyloxyphenylacetyl)pyrrolidine 

Relevant academic research and scientific papers

Compound for treating diabetes and/or related disorders

The invention discloses a compound for treating diabetes and/or related disorders, specifically a method for preventing, inhibiting and/or reversing amylin amyloid fibril formation, preventing isletsof Langerhans beta-cell death, preventing and/or reversing conversion of soluble human amylin to insoluble human amylin, and preventing and inhibiting and/or reversing cytotoxic amylin fibril formation. The invention also relates to a compound for preparing drugs for preventing and/or treating amylin amyloid-associated diseases.

COMPOUNDS FOR TREATING DIABETES AND/OR RELATED CONDITIONS

Compounds useful for treating or preventing diabetes and related conditions, and for preventing, inhibiting or reversing amylin-amyloid fibril formation, preventing islets of Langerhans (Beta)-cell death, preventing or reversing the transition from soluble human amylin to insoluble human amylin, preventing and inhibiting or reversing cytotoxic amylin fibril formation. The invention relates to compounds of Formula (I) and compounds of Formula (II): (Formulae (I) and (II)).

Synthesis of Substituted 6,7-Diphenyl-1,2,3,5,8,8a-hexahydroindolizines

Substituted 6,7-diphenyl-1,2,3,5,8,8a-hexahydroindolizines (28a to 28e) have been synthesized by two methods.In first method, condensation of substituted 2-phenacylpyrrolidines (24b to 24d) with substituted phenylacetylchlorides (2) affords substituted 2-