78183-93-4

Upstream product

• 78183-91-2 4'-nitrobenzyl 3-methyl-2-(2-chlorosulfinyl-4-oxo-3-phenoxyacetamido-1-azetidinyl)-3-butenoate 
• 78109-48-5 p-nitrobenzyl 3-methyl-2-(2-oxo-4-sulfino-3-phenoxyacetamido-1-azetidinyl)-3-butenoate 
• 78183-92-3 2-[(2R,3R)-2-Chloro-4-oxo-3-(2-phenoxy-acetylamino)-azetidin-1-yl]-3-methyl-but-3-enoic acid 4-nitro-benzyl ester 
• 78183-92-3 2-[(2R,3S)-2-Chloro-4-oxo-3-(2-phenoxy-acetylamino)-azetidin-1-yl]-3-methyl-but-3-enoic acid 4-nitro-benzyl ester 

Relevant academic research and scientific papers

Azetidinone Antibiotics. 22. A Rearrangement of Oxoazetidinesulfinic Acids to Haloazetidinones

Treatment of the oxoazetidinesulfinic acid 3 with a positive halogen source gave trans and cis 4-haloazetidinones 5; the trans isomer of 5 are easily converted to oxazoline 6 by chromatography on silica gel, while the cis isomers are transformed into 6 by