78109-48-5

Upstream product

• 78183-91-2 4'-nitrobenzyl 3-methyl-2-(2-chlorosulfinyl-4-oxo-3-phenoxyacetamido-1-azetidinyl)-3-butenoate 
• 109-99-9 tetrahydrofuran 
• 3481-09-2 N-chlorophthalimide 

Downstream Products

• 78109-51-0 p-Nitrobenzyl 3-methyl-2-(2-oxo-4-iodo-3-phenoxyacetamido-1-azetidinyl)-3-butenoate 
• 78183-92-3 2-[(2R,3S)-2-Chloro-4-oxo-3-(2-phenoxy-acetylamino)-azetidin-1-yl]-3-methyl-but-3-enoic acid 4-nitro-benzyl ester 
• 78183-93-4 3-Methyl-2-((1S,5R)-7-oxo-3-phenoxymethyl-4-oxa-2,6-diaza-bicyclo[3.2.0]hept-2-en-6-yl)-but-3-enoic acid 4-nitro-benzyl ester 
• 78183-92-3 2-[(2R,3R)-2-Chloro-4-oxo-3-(2-phenoxy-acetylamino)-azetidin-1-yl]-3-methyl-but-3-enoic acid 4-nitro-benzyl ester 
• 78109-49-6 2-[(2R,3R)-2-Fluoro-4-oxo-3-(2-phenoxy-acetylamino)-azetidin-1-yl]-3-methyl-but-3-enoic acid 4-nitro-benzyl ester 
• 78109-50-9 p-Nitrobenzyl 3-methyl-2-(2-oxo-4-bromo-3-phenoxyacetamido-1-azetidinyl)-3-butenoate 

Relevant academic research and scientific papers

Preparation of 4-haloazetidin-2-ones from 4-sulfinoazetidin-2-ones

Process for 4-halo azetidinones of the formula STR1 wherein R1 is acylamino or diacylamino, X is chloro, bromo or iodo, and R is a carboxy-protecting group which comprises treating a 4-sulfinoazetidinone of the formula STR2 with positive haloge

Azetidinone Antibiotics. 22. A Rearrangement of Oxoazetidinesulfinic Acids to Haloazetidinones

Treatment of the oxoazetidinesulfinic acid 3 with a positive halogen source gave trans and cis 4-haloazetidinones 5; the trans isomer of 5 are easily converted to oxazoline 6 by chromatography on silica gel, while the cis isomers are transformed into 6 by