78185-64-5

Usage

Uses

Used in Organic Synthesis:
Methyl 2-deoxy-3,5-di-O-p-toluoyl-α-D-ribo-furanoside is used as an intermediate in organic synthesis for the creation of complex organic molecules. Its stability and reactivity make it a useful building block in the synthesis of pharmaceuticals and other organic compounds.
Used in Research:
In the field of research, Methyl 2-deoxy-3,5-di-O-p-toluoyl-α-D-ribo-furanoside is utilized for studying carbohydrate chemistry and biochemistry. Its unique structure allows scientists to explore the interactions and properties of sugars in biological systems, contributing to a deeper understanding of carbohydrate-related processes.
Used in Drug Development:
Methyl 2-deoxy-3,5-di-O-p-toluoyl-α-D-ribo-furanoside is employed in the development of new drugs, particularly those targeting carbohydrate-related diseases or conditions. Its precise structure and properties make it a valuable tool for designing and testing potential therapeutic agents.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, Methyl 2-deoxy-3,5-di-O-p-toluoyl-α-D-ribo-furanoside is used as a key component in the synthesis of certain drugs. Its stability and reactivity contribute to the production of effective and reliable pharmaceutical products.
Used in Academic Research:
Methyl 2-deoxy-3,5-di-O-p-toluoyl-α-D-ribo-furanoside is utilized in academic research settings to advance the understanding of carbohydrate chemistry and its role in biological processes. Methyl 2-deoxy-3,5-di-O-p-toluoyl-α-D-ribo-furanoside serves as a valuable research tool for scientists and researchers in universities and research institutions.

Upstream product

• 874-60-2 4-methyl-benzoyl chloride 
• 51255-17-5 1-O-methyl-2-deoxy-D-ribofuranoside 
• 533-67-5 2-Deoxy-D-ribose 
• 67-56-1 methanol 
• 452-51-7 D-2-deoxyribose 

Downstream Products

• 4330-21-6 2-deoxy-3,5-di-O-p-toluoyl-α-D-erythro-pentofuranosyl chloride 
• 871667-92-4 2'-deoxy-5-iodouridine 
• 871664-01-6 5-iodo-2'-deoxy-3',5'-di-O-p-toluoyl-uridine 
• 862100-45-6 5-cyanovinyl-2'-deoxy-5'-dimethoxytrityl-1'α-uridine 

Relevant academic research and scientific papers

Preparation of pyridine-stretched 2′-deoxyhypoxanthosine phosphoramidite

Pyridine-stretched 2-deoxyhypoxanthosine (strH) phosphoramidite was prepared in eight steps from Hoffer's sugar (2-deoxy-3,5-di-O-(p-toluoyl)-a-D-erythro-pentofuranosyl chloride). Improved synthesis of the Hoffer sugar was achieved without need for distillation or chromatographic separation of intermediates, or use of gaseous HCl. Conditions were optimised to provide a key nitrile intermediate for the preparation of strH whereby the cesium salt of 4(5)-nitroimidazole was glycosylated using Hoffer's sugar. The nitrile intermediate was also used to prepare pyridine-stretched 2-deoxyadenosine (strA) and pyridine-stretched 2-deoxy-2,6-diaminonebulamine (strD). Preliminary studies indicate that strH forms a stronger, size-expanded base pair with adenine compared with the Watson-Crick thymine-adenine base pair.

Template-directed DNA photoligation via α-5-cyanovinyldeoxyuridine

(Chemical Equation Presented) We describe an efficient template-directed photoligation of oligodeoxynucleotides (ODNs) using α-5- cyanovinyldeoxyuridine (αcU). An efficient photoligation was produced by photoirradiation of an ODN containing thymine at the 5′ end with an ODN containing thymine at the 5′ end in the presence of a template ODN. This photoligation method is a new and efficient way to synthesize branched ODNs.

Improved Syntheses of Halofuranose Derivatives with the Desired α-Configuration

Chlorination of ribofuranose or 2-deoxyribofuranose derivatives was carried out in a 1,4-dioxane solution of hydrogen chloride. This improved procedure allowed the syntheses of 1-chloro-α-D-ribofuranose and 1-chloro-2-deoxy-α-D-ribofuranose derivatives and offered ease of handling, high yield, and the stereo-controlled α-configuration at C-1.