78191-66-9Relevant academic research and scientific papers
Direct Access to Isotopically Labeled Aliphatic Ketones Mediated by Nickel(I) Activation
Donslund, Aske S.,Pedersen, Simon S.,Gaardbo, Cecilie,Neumann, Karoline T.,Kingston, Lee,Elmore, Charles S.,Skrydstrup, Troels
supporting information, p. 8099 - 8103 (2020/03/16)
An extensive range of functionalized aliphatic ketones with good functional-group tolerance has been prepared by a NiI-promoted coupling of either primary or secondary alkyl iodides with NN2 pincer NiII-acyl complexes. The latter were easily accessed from the corresponding NiII-alkyl complexes with stoichiometric CO. This Ni-mediated carbonylative coupling is adaptable to late-stage carbon isotope labeling, as illustrated by the preparation of isotopically labelled pharmaceuticals. Preliminary investigations suggest the intermediacy of carbon-centered radicals.
Gas-phase pyrolytic reaction of 3-anilino-1-propanol derivatives: kinetic and mechanistic study
Ibrahim,Al-Awadi,Ibrahim,Patel,Al-Awadi
, p. 4768 - 4772 (2007/10/03)
3-Anilino-1-propanol derivatives 4a-c, 5a-c, 6a-c containing primary, secondary, and tertiary alcohols and PhNH, PhNMe, and (Ph)2N were prepared and subjected to gas-phase pyrolysis in a static reaction system. The pyrolytic reactions were homogeneous and followed a first-order rate equation. Reactions took place by retro-ene process, with the exception of compounds 5a and 5b. Analysis of the pyrolysate showed the products to be N-substituted aniline and carbonyl compounds. The kinetic results and product analysis of each of the nine investigated 3-amino alcohols are rationalized in terms of a plausible transition state for the elimination pathway.
HYDROBORATION D'AMINES ALLYLIQUES. REACTIVITE DES ORGANOBORANES
Baboulene, Michel,Torregrosa, Jean-Luc,Speziale, Vincent,Lattes, Armand
, p. 565 - 570 (2007/10/02)
Hydroboration of differently substituted allylic amines has been studied systematically.It was possible to demonstrate the importance of the hydroboration agent on the formation of aminoboranes.Oxidation of aminoboranes by hydrogen peroxyde in basic medium has ben examined and has led, with good yields, to primary aminoalcohols or a mixture of isomeric aminoalcohols.The influence of steric hindrance on the double bond and that of substitution of the nitrogen atom have been shown.
