782-02-5

Upstream product

• 100-42-5 styrene 
• 120-80-9 benzene-1,2-diol 
• 5186-08-3 3-(1-phenyl-ethyl)-pentane-2,4-dione 
• 91-16-7 1,2-dimethoxybenzene 
• 98-85-1 1-Phenylethanol 

Relevant academic research and scientific papers

Simple Method for sp2-sp3 and sp3-sp3 Carbon-Carbon Bond Activation in 2-Substituted 1,3-Diketones

Simple and efficient methods were developed for sp2-sp3 and sp3-sp3 C-C bond-activation reactions of 2-substituted 1,3-diketones. 3-Substituted 3-bromopentane-2,4-diones were deacylated in the presence of an aromatic compound and a silica gel supported Bronsted acid containing sulfonic groups. The carbocation formed by cleavage of the sp3-sp3 C-C bond of the dione alkylated the aromatic compound.

Hydroarylation of styrenes with electron-rich arenes over acidic ion-exchange resins

A series of acidic cation-exchange resins were used for the hydroarylation of resorcinol with styrene, in which resin D072 exhibited the excellent catalytic performance in this reaction with 99% conversion of styrene and 90% selectivity of 4-(1-phenylethyl)resorcinol. It was applied to the hydroarylation of various electron-rich arenes with styrenes, and the hydroarylated products were quantitatively obtained. This catalyst could be used for four consecutive runs with slight decrease in activity. The hydroarylation of resorcinol with styrene over resin D072 in a fixed bed was completed effectively with 94% selectivity and 99% conversion, and this green continuous process is potentially applicable to large-scale productions.

Microwave-accelerated alkylation of arenes/heteroarenes with benzylic alcohols using antimony(III) chloride as catalyst: Synthesis of O-heterocycles

An efficient protocol for alkylation of electron-rich arenes/heteroarenes with benzylic alcohols under microwave irradiation using antimony(III) chloride as catalyst has been developed. The mild reaction conditions, high yields, operational simplicity, and applicability to various substrates render the approach a useful route for the synthesis of diaryl/triarylalkane. In addition, a new route for the conversion of ortho-alkenylated phenols into functionalized O-heterocycles has been accomplished. Georg Thieme Verlag Stuttgart ? New York.

Antioxidant activities of dihydric phenol derivatives for the autoxidation of tetralin

The antioxidant activities of dihydric phenols, such as catechol, resorcinol, and hydroquinone, and their twenty-three alkyl and benzyl substituted derivatives were evaluated by means of an oxygen-absorption method at 60°C for determining the oxidation of tetralin. Catechols exhibited a much higher stoichiometric factor (2.0-2.3) compared with those of other compounds. The stoichiometric factors of hydroquinones (0.6-1.1) are almost half those of catechols, and are lower for the resorcinols (0.3-0.6). In addition, the rates of oxidation during the induction period (R(inh)) were 1.1-1.6 x 10-6, 3.0-3.8 x 10-6, and 13.3-18.4 x 10-6 M min-1 for catechols, hydroquinones, and resorcinols, respectively. According to these results, catechols and hydroquinones are efficient antioxidants, and their activities may be dependent on the stability of phenoxyl radicals as oxidation products due to the formation of the quinone structure. Furthermore, the stability of phenoxyl radicals derived from catechols is higher than that of those from hydroquinones. In spite of having two OH substituents, resorcinols behave as monohydric phenols in the reaction with peroxyl radicals.

REACTION OF PYROCATECHOL AND RESORCINOL WITH STYRENE IN THE PRESENCE OF ALUMINUM PHENOLATE

The alkylation of pyrocatechol and resorcinol with styrene in the presence of aluminum phenolate leads to a mixture of isomeric (α-methylbenzyl)dihydroxybenzenes, in which the ortho-alkylation products as a rule predominate.

Hypolipidemic substituted 1,3 benzodioxole 2 carboxylates

Ethyl 5 (4 fluoro α,α dimethylbenzyl) 1,3 benzodioxole 2 carboxylate (11, RMI 14,676) was found to be a potent hypolipidemic agent, while ethyl 5 (1 phenyl 1 cyclopentyl) 1,3 benzodioxole 2 carboxylate (19, RMI 14,654), although less potent, was found to