78211-08-2Relevant academic research and scientific papers
Synthesis of Some N-Substituted Aminoacyl- and Dipeptide and Tripeptide Derivatives of 3-Amino-2-imino-2,3-dihydrothiazoloquinoxaline, 2-Aminothiazoloquinoxaline and 2-Hydrazino-4H-1,3,4-thiadiazinoquinoxaline
El-Naggar, A. M.,El-Salam, A. M. Abd,Ismail, I. M.,Haroun, B. M.,Gommaa, A. M.
, p. 1088 - 1091 (2007/10/02)
Some 3-(N-Tos- or N-Pht-aminoacyl)amino-2-imino-2,3-dihydrothiazoloquinoxalines and the corresponding 2-aminothiazoloquinoxalines and 2-hydrazino-4(H)-1,3,4-thiadiazinoquinoxaline derivatives (IV-XXXVI) have been synthesized and screened for their biological activities.Hydrazinolysis of the N-phthalyl derivatives in ethanol affords the unprotected amino acid derivatives (XXXVII-XLII). 3-(N-Tos-di- and tripeptide)amino-2-imino-2,3-dihydrothiazolo-quinoxaline, 2-(N-Tos-di- and tripeptide)aminothiazoloquinoxaline and 2-(N-Tos-di- and tripeptide)hydrazino-4(H)-1,3,4-thiadiazino-quinoxaline derivatives (XLIII-LIV) have been synthesized via the azide method.Amongst the compounds synthesized, VII, IX, XVI, XX, XXI, XXVIII, XXIX, XXXII, XXXIX, XLII, XLV-XLVII, XLIX and LI-LIV are found to be active against a number of microorganisms.
