78221-01-9Relevant academic research and scientific papers
Synthesis of Some Biologically Active 2-Aminobenzothiazole Derivatives with Tosylamino, Phthalylaminoacyl, Aminoacyl, N-Tosyldi and Tripeptidyl Substituents at 2-Position
El-Naggar, A. M.,El-Salam, A. M. Abd,Gommaa, A. M.
, p. 1068 - 1070 (2007/10/02)
The synthesis of some 2-(N-tosyl- and N-phthalyl-aminoacyl)aminobenzothiazoles (II-XIV) is described.Coupling of N-tosyl- or N-phthalylamino acids with 2-aminobenzothiazole using dicyclohexylcarbodiimide furnishes the desired derivates (II-XIV).Hydrazinolysis of 2-(N-Pht-Gly)-(IX)- and 2-(N-Pht-Ala)-(X)-aminobenzothiazoles in ethanol affords 2-(Gly)-(XV)- and 2-(Ala)-(XVI)-aminobenzothiazoles respectively.The different 2-(N-Tos-di- and tri-peptidyl)aminobenzothiazoles (XVII-XX) have been obtained via the azide method.Compounds (V, VII, VIII, IX, XV, and XVII-XX) are found to be active against a number of microorganisms.
