78234-11-4Relevant academic research and scientific papers
Synthesis and QSAR studies on hypotensive 1-[3-(4-substituted phenylthio) propyl]-4-(substituted phenyl) piperazines
Saxena, Anil K.,Rao, Jyoti,Chakrabarty, Ruchika,Saxena, Mridula,Srimal
, p. 1708 - 1712 (2007/10/03)
A series of 1-[3-(4-substituted phenylthio) propyl]-4-(substituted phenyl) piperazines has been synthesized and evaluated for hypotensive activity. The QSAR studies indicate that resonance and hydrophobic parameters of the aryl substituents are important
Fourier transform infrared spectra and normal mode analysis of 1-[(3-methylphenyl)piperazin-1-yl]-3-[thio(4-acetamido- phenyl]propane: A potent 5-HT2 and D2 receptor ligand
Singh, Rajendra B.,Gupta, Dinesh C.,Bajpai, Umesh C.,Saxena, Mridula,Saxena, Anil K.
, p. 1267 - 1275 (2007/10/03)
1-[(3-methylphenyl)piperazin-1-yl]-3-[Thio(4- acetamidophenyl]propane and its analogs have shown good hypotensive activity and the title compound has shown a profile of centrally acting anti-hypertensive agent. It also binds with the 5-HT2 rece
Synthesis of N-heterocyclics as Potential CNS/CVS Agents
Rao, Jyoti,Saxena, Anil K.,Saxena, R. M.,Singh, H. K.,Kar, K.,Srimal, R. C.
, p. 761 - 765 (2007/10/02)
A number of N-heterocyclics (6-13, 19-21) have been synthesized by the condensation of γ-chloropropylaryl sulphides and sulphones (3-5 and 18) with appropriate nitrogen heterocyclics.The 4-aminophenyl derivatives in case of su
Inhibitor of dihydrofolate reductase
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, (2008/06/13)
A group of aryl-Z-alkoxy-5-benzylpyrimidines wherein Z is oxy, thio, imino, carbonyl, carbamoyl, sulfonyl, sulfinyl or sulfamoyl has been prepared from 2,4-diamino-5-benzylpyrimidine via alkylation with either an aryl-Z-alkyl halide or a substituted glyci
