78247-61-7Relevant academic research and scientific papers
Novel multicomponent reaction for the combinatorial synthesis of 2-imidazolines
Bon, Robin S.,Hong, Chongen,Bouma, Marinus J.,Schmitz, Rob F.,De Kanter, Frans J. J.,Lutz, Martin,Spek, Anthony L.,Orru, Romano V. A.
, p. 3759 - 3762 (2007/10/03)
(Matrix presented) The three-component condensation between an amine, an aldehyde, and an α-acidic isocyanide efficiently provides substituted 2-imidazolines in a one-pot reaction under mild conditions.
A mild method for formylating amino esters without using any formulating agent
Giard, Thierry,Bénard, Didier,Plaquevent, Jean-Christophe
, p. 297 - 300 (2007/10/03)
A simple and mild method for the N-formylation of α-amino esters is described via an intermediate oxaziridine. This procedure avoids the necessity of specific formylating agents and yields the N-formyl species in high yield and without racemization.
SYNTHESE D'AMINOPHOSPHINEPHOSPHINITES CHIRAUX. UTILISATION EN REDUCTION ASYMETRIQUE CATALYTIQUE
Karim, A.,Mortreux, A.,Petit, F.,Buono, G.,Pfeiffer, G.,Siv, C.
, p. 93 - 104 (2007/10/02)
The chiral aminophosphinephosphinites ligands (AMPP) are directly synthesized from natural amino alcohols or by reduction of formyl esters of α-amino acids and PPh2Cl. Their cationic rhodium complexes have been found to be excellent catalysts for enantioselective hydrogenation of dehydroamino acids (ee ca. 86percent, yield ca. 100percent) for example.Asymmetric reduction of ketones can also be performed with the new alkyl AMPP* modified rhodium catalyst (ee 50percent).
