782479-20-3Relevant academic research and scientific papers
Total synthesis and structural elucidation of azaspiracid-1. Final assignment and total synthesis of the correct structure of azaspiracid-1
Nicolaou,Koftis, Theocharis V.,Vyskocil, Stepan,Petrovic, Goran,Tang, Wenjun,Frederick, Michael O.,Chen, David Y.-K.,Li, Yiwei,Ling, Taotao,Yamada, Yoichi M. A.
, p. 2859 - 2872 (2007/10/03)
The molecular structure of azaspiracid-1, a neurotoxin isolated from mussels, has been elucidated by total synthesis which also enriched its supplies. The degradatively derived fragments of this marine biotoxin, compounds 5 (EFGHI), 6 (FGHI), and 40 (ABCD
Total synthesis and confirmation of the revised structures of azaspiracid-2 and azaspiracid-3
Nicolaou,Frederick, Michael O.,Petrovic, Goran,Cole, Kevin P.,Loizidou, Eriketi Z.
, p. 2609 - 2615 (2007/10/03)
The 39 steps: The recently proposed revised structures of azaspiracid-2 and -3 (see picture), the two most potent members of the azaspiracid family, have been confirmed through the total syntheses of the two compounds. These 39-step syntheses represent a
Structural revision and total synthesis of azaspiracid-1, part 2: Definition of the ABCD domain and total synthesis
Nicolaou,Koftis, Theocharis V.,Vyskocil, Stepan,Petrovic, Goran,Ling, Taotao,Yamada, Yoichi M. A.,Tang, Wenjun,Frederick, Michael O.
, p. 4318 - 4324 (2007/10/03)
The chase for the structure of azaspiracid-1 has ended with a revised structure (see picture). The total synthesis of this challenging target has closed another chapter in this intriguing chemical detective story and allowed the assignment of the relative
