782499-18-7Relevant articles and documents
Rational design of a nonpeptide general chemical scaffold for reversible inhibition of PDZ domain interactions
Fujii, Naoaki,Haresco, Jose J.,Novak, Kathleen A.P.,Gage, Robert M.,Pedemonte, Nicoletta,Stokoe, David,Kuntz, Irwin D.,Kiplin Guy
, p. 549 - 552 (2007/10/03)
Novel small molecules were designed to specifically target the ligand-binding pocket of a PDZ domain. Iterative molecular docking and modeling allowed the design of an indole scaffold 10a as a reversible inhibitor of ligand binding. The 10a scaffold inhib