78270-90-3

Basic information

• Product Name: 2-phenylpyrimidine-4,5,6-triamine
• Synonyms: 2-phenylpyrimidine-4,5,6-triamine
• CAS NO: 78270-90-3
• Molecular Weight: 201.231
• Mol File: 78270-90-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-phenylpyrimidine-4,5,6-triamine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-phenylpyrimidine-4,5,6-triamine(78270-90-3)
• EPA Substance Registry System: 2-phenylpyrimidine-4,5,6-triamine(78270-90-3)

Safety Data

• Hazardous Substances Data: 78270-90-3(Hazardous Substances Data)

Upstream product

• 7152-36-5 isonitrosomalononitrile benzamidine salt 
• 56472-04-9 4,6-diamino-5-nitroso-2-phenylpyrimidine 
• 101352-53-8 2-phenyl-5-phenylazo-pyrimidine-4,6-diyldiamine 

Downstream Products

• 1084-59-9 4-amino-2-phenylpteridine 
• 1501-45-7 2-phenyl-7⁽⁹⁾H-purin-6-ylamine 
• 29984-62-1 4-amino-2-phenyl-7(8H)-pteridinone 
• 106823-69-2 8-(2'-dimethylaminoethylthio)-2-phenylpurin-6-amine 
• 78241-68-6 2-phenyl-4-amino-6,7-acenaphthenopteridine 
• 78241-67-5 2-phenyl-4-amino-6,7-phenanthrenopteridine 

Relevant articles and documents

Nucleosides part LXVI I[1]: Synthesis of 4-amino-7(8H) pteridinone-N8-nucleosides-structural analogs of adenosine

Various 4-amino-7(8H)pteridones (6, 12, 14, 15, 20, 22) have been glycosylated with 1-chloro-2'-deoxy-D-ribofuranose derivatives (25, 26) applying the new DBU-salt method to form the N8-2'-deoxy-D-ribofuranosides (27-36) which can be regarded as 2'-deoxyadenosine analogs. Analogously reacted the 2-N,N-dimethyl-amino-methyleneimino-7(8H)pteridones (43-48) to give preferentially the corresponding N8-ss-D-anomers (49-55). Ribosylation with 1-bromo-2,3,5-tri-O-benzoyl-a-D-ribofuranose (56) proceeded as well with 6, 12, 15, 45, and 46 to yield to N8-ss-D-ribofuranosides 57-61. Sugar deprotection led to the free N8-2'-deoxy-ss-D-ribofuranosides 37-42 and N8-ss-D-ribofurano-sides 62-65, respectively. Glycosylations via the silyl-method under Vorbruggen conditions led with 6, 12 and 15 to the same results, however, 4-amino-6-phenyl-7(8H)pteridone (14) reacted differently forming the N1-ss-D-ribofuranosides (71, 79) and the N1-2'-deoxy - and ss-D-ribofuranosides 73, 74, 77, 78. The assignments of the structures have been achieved by 1H-NMR- and UV-spectra. C,H,N-elemental analyses account for the composition.

Inhibition of neuronal nitric oxide synthase by 4-amino pteridine derivatives: Structure-activity relationship of antagonists of (6R)-5,6,7,8- tetrahydrobiopterin cofactor

The family of nitric oxide synthases (NOS) catalyzes the conversion of L-arginine to L-citrulline and nitric oxide (NO), an important cellular messenger molecule which has been implicated in the pathophysiology of septic shock and inflammatory and neurode