78282-65-2Relevant academic research and scientific papers
Evaluation of monoquaternary pyridinium oximes potency to reactivate tabun-inhibited human acetylcholinesterase
Odzak, Renata,Calic, Maja,Hrenar, Tomica,Primozic, Ines,Kovarik, Zrinka
, p. 85 - 96 (2007)
Monoquaternary N-benzyl-4-hydroxyiminomethylpyridinium bromide (Py-4-H) and its analogous with diverse substituents introduced into the phenyl ring (Py-4-CH3, Py-4-Br, Py-4-Cl and Py-4-NO2) were synthesized in order to examine their
Monoquaternary pyridinium salts with modified side chain-synthesis and evaluation on model of tabun- and paraoxon-inhibited acetylcholinesterase
Musilek, Kamil,Kucera, Jiri,Jun, Daniel,Dohnal, Vlastimil,Opletalova, Veronika,Kuca, Kamil
scheme or table, p. 8218 - 8223 (2009/04/11)
Acetylcholinesterase reactivators are crucial antidotes for the treatment of organophosphate intoxication. Eighteen monoquaternary reactivators of acetylcholinesterase with modified side chain were developed in an effort to extend the properties of pralidoxime. The known reactivators (pralidoxime, HI-6, obidoxime, trimedoxime, methoxime) and the prepared compounds were tested in vitro on a model of tabun- and paraoxon-inhibited AChE. Monoquaternary reactivators were not able to exceed the best known compounds for tabun poisoning, but some of them did show reactivation better or comparable with pralidoxime for paraoxon poisoning. However, extensive differences were found by a SAR study for various side chains on the non-oxime part of the reactivator molecule.
