78290-80-9Relevant academic research and scientific papers
A Bench-Stable Vilsmeier Reagent for in situ Alcohol Activation: Synthetic Application in the Synthesis of 2-Amino-2-Thiazolines
Corbett, Michael T.,Caille, Seb
supporting information, p. 2845 - 2850 (2017/10/06)
A robust, chemoselective direct condensation/cyclization of thioureas and amino alcohols is described. Employing a bench-stable Vilsmeier reagent, methoxymethylene- N, N -dimethyliminium methyl sulfate, the selective in situ activation of alcohols is achieved with high efficiency and broad functional-group tolerance. The reversible interaction of the Vilsmeier reagent with substrate was key to the success of this activation strategy.
Glycerine and CeClH: An efficient and recyclable reaction medium for ring opening of epoxides with thioamides and amines
Narsaiah, A. Venkat,Wadavrao, Sachin B.,Reddy, A. Ramesh,Yadav
experimental part, p. 485 - 489 (2011/04/16)
Oxiranes undergo rapid ring-opening reaction with a range of thioamides and amines to afford the corresponding -amino alcohol derivatives. The reactions were carried out using glycerine and cerium(III) chloride as a recyclable reaction medium. All the reactions were carried out at room temperature and the products were obtained in excellent yields. Georg Thieme Verlag Stuttgart New York.
A selective and convenient method for the synthesis of 2- phenylaminothiazolines
Bernacki, April L.,Zhu, Lingyang,Hennings, D. David
supporting information; experimental part, p. 5526 - 5529 (2011/02/24)
A series of 2-phenylaminothiazolines have been prepared from the corresponding N-(2-hydroxyethyl)-N'-phenylthioureas under mild reaction conditions using either thio-CDI (1,1'-thiocarbonyldiimidazole) or CDI (1,1'-carbonyldiimidazole) to promote the cycli
