78299-75-9

Basic information

• Product Name: 5-BENZYLOXY-1H-INDAZOLE
• Synonyms: 5-BENZYLOXY-1H-INDAZOLE;1H-Indazole, 5-(phenylmethoxy)-;5-(Benzyloxy)indazole;5-(Phenylmethoxy)-1H-indazole
• CAS NO: 78299-75-9
• Molecular Formula: C₁₄H₁₂N₂O
• Molecular Weight: 224.26
• Product Categories: pharmacetical
• Mol File: 78299-75-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 422.4 °C at 760 mmHg
• Flash Point: 152.5 °C
• Appearance: /
• Density: 1.247 g/cm³
• Vapor Pressure: 5.94E-07mmHg at 25°C
• Refractive Index: 1.677
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 13.52±0.40(Predicted)
• CAS DataBase Reference: 5-BENZYLOXY-1H-INDAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BENZYLOXY-1H-INDAZOLE(78299-75-9)
• EPA Substance Registry System: 5-BENZYLOXY-1H-INDAZOLE(78299-75-9)

Safety Data

• Hazardous Substances Data: 78299-75-9(Hazardous Substances Data)

Usage

General Description

5-BENZYLOXY-1H-INDAZOLE is a chemical compound with the molecular formula C15H13N. It is a benzyl ether derivative of the heterocyclic compound indazole, which is commonly used as a building block in the synthesis of various pharmaceuticals and agrochemicals. 5-BENZYLOXY-1H-INDAZOLE is known for its antimicrobial and antifungal properties, and it has also been studied for its potential use in the treatment of cancer and inflammation. The compound is often used as a reagent in organic synthesis and medicinal chemistry research due to its versatile reactivity and biological activity.

InChI:InChI=1/C14H12N2O/c1-2-4-11(5-3-1)10-17-13-6-7-14-12(8-13)9-15-16-14/h1-9H,10H2,(H,15,16)

Upstream product

• 15579-15-4 5-hydroxy-1H-indazole 
• 100-39-0 benzyl bromide 
• 102-50-1 2-methyl-4-methoxyaniline 
• 94444-96-9 5-methoxy-1H-indazole 

Downstream Products

• 854632-98-7 5-(benzyloxy)-3-iodo-1H-indazole 
• 1338792-79-2 3-(5-(benzyloxy)-1H-indazol-3-yl)benzenesulfonamide 
• 1613301-14-6 4-(5-benzyloxyindazol-1-yl)-2-methylbutan-2-ol 

Relevant articles and documents

Discovery of inhibitors of the mitotic kinase TTK based on N-(3-(3-sulfamoylphenyl)-1H-indazol-5-yl)-acetamides and carboxamides

TTK kinase was identified by in-house siRNA screen and pursued as a tractable, novel target for cancer treatment. A screening campaign and systematic optimization, supported by computer modeling led to an indazole core with key sulfamoylphenyl and acetamido moieties at positions 3 and 5, respectively, establishing a novel chemical class culminating in identification of 72 (CFI-400936). This potent inhibitor of TTK (IC50 = 3.6 nM) demonstrated good activity in cell based assay and selectivity against a panel of human kinases. A co-complex TTK X-ray crystal structure and results of a xenograft study with TTK inhibitors from this class are described.

Rho KINASE INHIBITORS

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