78303-43-2Relevant academic research and scientific papers
The salt-free nickel-catalysed α-allylation reaction of ketones with allyl alcohol and diallylether
Mouhsine, Bouchaib,Karim, Abdallah,Dumont, Clément,Sauthier, Mathieu
supporting information, p. 950 - 955 (2020/02/25)
The nickel-catalysed α-allylation of ketones with allyl alcohol and diallylether has been performed under neutral conditions. As no base is involved, the products are synthesized without salts as side products. The dppf/Ni(cod)2 catalytic system in MeOH at 80 °C has been shown as the most effective reaction system to afford tetrasubstituted derivatives from various cyclic and acyclic ketones with one or two mobile protons. This process combined with a metathesis step yields spirocyclic compounds according to a salt free synthetic sequence.
Platinum(IV)-Catalyzed Synthesis of Unsymmetrical Polysubstituted Benzenes via Intramolecular Cycloaromatization Reaction
Zheng, Shuyan,Zhang, Jinghua,Shen, Zhengwu
supporting information, p. 2803 - 2808 (2015/09/28)
A one-pot synthesis of polysubstituted benzene derivatives was achieved via a platinum(IV)-catalyzed intramolecular cycloaromatization reaction. The reaction proceeds via a tandem skeletal rearrangment, dehydration and double bond isomerization, which proved to be very useful for the syntheses of a range of interesting polyalkyl-substituted benzenes.
Nucleophilic α-arylation and α-alkylation of ketones by polarity inversion of N-alkoxyenamines: Entry to the umpolung reaction at the α-carbon position of carbonyl compounds
Miyoshi, Tetsuya,Miyakawa, Takayuki,Ueda, Masafumi,Miyata, Okiko
supporting information; experimental part, p. 928 - 931 (2011/04/14)
A new aspect of enamine chemistry: The formation of N-alkoxyenamines from ketones has led to an efficient umpolung reaction. The alkylation of N-alkoxyenamines with trialkylaluminum compounds proceeded smoothly and gave α-alkylated ketones (see scheme). This reaction offers a simple transformation of ketones into α-substituted ketones without the need to isolate enamines and intermediary imines.
REACTION OF ALLYLSILANE WITH α-NITRO OLEFIN AND ITS DEVELOPMENT TO SYNTHESIS OF CYCLOPENTENONE
Ochiai, Masahito,,Arimoto, Masao,Fujita, Eiichi
, p. 1115 - 1118 (2007/10/02)
Michael addition of allylsilane to α-nitro olefin in the presence of AlCl3 proceeded smoothly at low temperature to give unsaturated nitronic acid, which was converted into the γδ-enone using aqueous Ti (III).Transformation of the enone into the 1,4-diketone followed by the intramolecular aldol condensation with the latter provided a convenient new synthesis of cyclopentanone.
