37629-51-9

Basic information

• Product Name: 1-(4-METHOXYPHENYL)-2-NITROPROPENE
• Synonyms: 1-(4-METHOXYPHENYL)-2-NITROPROPENE;4'-METHOXY-BETA-METHYL-BETA-NITROSTYRENE;1-methoxy-4-[(E)-2-nitroprop-1-enyl]benzene
• CAS NO: 37629-51-9
• Molecular Formula: C₁₀H₁₁NO₃
• Molecular Weight: 193.2
• Mol File: 37629-51-9.mol
• Article Data: 33

Chemical Properties

• Boiling Point: 321.7°C at 760 mmHg
• Flash Point: 147.4°C
• Appearance: /
• Density: 1.156g/cm³
• Vapor Pressure: 0.000551mmHg at 25°C
• Refractive Index: 1.568
• CAS DataBase Reference: 1-(4-METHOXYPHENYL)-2-NITROPROPENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-METHOXYPHENYL)-2-NITROPROPENE(37629-51-9)
• EPA Substance Registry System: 1-(4-METHOXYPHENYL)-2-NITROPROPENE(37629-51-9)

Safety Data

• Hazardous Substances Data: 37629-51-9(Hazardous Substances Data)

Usage

General Description

1-(4-Methoxyphenyl)-2-nitropropene is a chemical compound with the molecular formula C10H11NO3. It is a yellowish-brown liquid with a strong, sweet, and floral odor. 1-(4-METHOXYPHENYL)-2-NITROPROPENE is used in the synthesis of pharmaceuticals and as a precursor in the production of other organic compounds. It is known to be a mutagen and should be handled with care. 1-(4-Methoxyphenyl)-2-nitropropene is not commonly found in nature and is typically synthesized in the laboratory. It is important to follow safety protocols when handling this compound due to its potential health hazards.

InChI:InChI=1/C10H11NO3/c1-8(11(12)13)7-9-3-5-10(14-2)6-4-9/h3-7H,1-2H3/b8-7+

Upstream product

• 123-11-5 4-methoxy-benzaldehyde 
• 104-46-1 anethole 
• 79-24-3 Nitroethane 
• 105-13-5 4-Methoxybenzyl alcohol 
• 4180-23-8 E-1-(4'-methoxyphenyl)prop-1-ene 
• 13048-81-2 (E)-3-(4-methoxyphenyl)-2-methylacrylic acid 
• 591-31-1 3-methoxy-benzaldehyde 
• 148527-33-7 2-nitro-1-hydroxy-1-(4-methoxy-phenyl)-propane 
• 148527-35-9 1-(4-methoxyphenyl)-2-nitropropyl acetate 

Downstream Products

• 64-13-1 2-amino-1-(4-methyoxyphenyl)propane 
• 89447-02-9 2,5-dimethyl-4-(4-methoxyphenyl)furan-3-carboxylic acid methylester 
• 128224-95-3 (E)-1-(4-methoxyphenyl)propan-2-one oxime 
• 929878-88-6 4-(4-methoxyphenyl)-3,6,6-trimethyl-5,6-dihydro-4H-1,2-oxazine 2-oxide 
• 1619943-34-8 4-(4-methoxyphenyl)-5-methyl-2-(methylthio)-1-phenyl-3-(4-trifluoromethyl)pyrrole 
• 1619943-35-9 3-(2-furoyl)-4-(4-methoxyphenyl)-5-methyl-2-(methylthio)-1-phenylpyrrole 
• 1453201-22-3 (R)-1-methoxy-4-(2-nitropropyl)benzene 

Relevant articles and documents

Discovery of Cytochrome P450 4F11 Activated Inhibitors of Stearoyl Coenzyme A Desaturase

Stearoyl-CoA desaturase (SCD) catalyzes the first step in the conversion of saturated fatty acids to unsaturated fatty acids. Unsaturated fatty acids are required for membrane integrity and for cell proliferation. For these reasons, inhibitors of SCD represent potential treatments for cancer. However, systemically active SCD inhibitors result in skin toxicity, which presents an obstacle to their development. We recently described a series of oxalic acid diamides that are converted into active SCD inhibitors within a subset of cancers by CYP4F11-mediated metabolism. Herein, we describe the optimization of the oxalic acid diamides and related N-acyl ureas and an analysis of the structure-activity relationships related to metabolic activation and SCD inhibition.

INDOLE AHR INHIBITORS AND USES THEREOF

The present invention provides compounds useful as inhibitors of AHR, compositions thereof, and methods of using the same.

Enantioselective hydrogenation of α,β-disubstituted nitroalkenes

The first highly chemo- and enantioselective hydrogenation of α,β-disubstituted nitroalkenes was accomplished with rhodium/JosiPhos-J2 as a catalyst, with the yield and enantioselectivity of up to 95% and 94%, respectively. The α-chiral nitroalkanes will provide an entry to valuable chiral amphetamines which are otherwise not so easily accessed. This journal is the Partner Organisations 2014.