78307-39-8

Upstream product

• 186581-53-3 diazomethane 
• 22818-40-2 D-4-hydroxyphenylglycine 
• 109012-91-1 (2S,5R)-2-Isopropyl-3,6-dimethoxy-5-(4-methoxy-phenyl)-2,5-dihydro-pyrazine 
• 193073-85-7 methyl (R)-2-((tert-butoxycarbonyl)amino)-2-(4-methoxyphenyl)acetate 

Downstream Products

• 135875-44-4 (S)-[(2R,3R)-3-Hydroxy-4-methyl-2-(2-oxo-4,5-diphenyl-oxazol-3-yl)-pent-4-enoylamino]-(4-methoxy-phenyl)-acetic acid methyl ester 
• 100929-33-7 (R)-2-amino-2-(4-methoxyphenyl)-1-ethanol 
• 193073-96-0 [(2S)-2-(tert-butoxycarbonylmethylamino)-3-(4-fluoro-3-nitrophenyl)propionylamino]-(R)-(4-methoxyphenyl)methyl ester 
• 401895-83-8 (R)-[(R)-2-Benzyloxycarbonylamino-2-(3,5-bis-benzyloxy-4-methoxy-phenyl)-acetylamino]-(4-methoxy-phenyl)-acetic acid methyl ester 
• 193073-99-3 [3-(4-fluoro-3-nitrophenyl)-(2S)-2-methylaminopropionylamino]-(R)-(4-methoxyphenyl)acetic acid methyl ester 
• 193074-05-4 [2-{(R)-[amino-(3,5-dichloro-4-methoxyphenyl)acetyl]methylamino}-(3S)-3-(4-fluoro-3-nitrophenyl)propionylamino]-(R)-(4-methoxyphenyl)acetic acid methyl ester 
• 249757-19-5 (R)-[(S)-2-{[(S)-2-Amino-2-(3,5-dichloro-4-methoxy-phenyl)-acetyl]-methyl-amino}-3-(4-fluoro-3-nitro-phenyl)-propionylamino]-(4-methoxy-phenyl)-acetic acid methyl ester 
• 193074-02-1 [2-{(R)-[tert-butoxycarbonylamino-(3,5-dichloro-4-methoxyphenyl)acetyl]methylamino}-(3S)-3-(4-fluoro-3-nitrophenyl)propionylamino]-(R)-(4-methoxyphenyl)acetic acid methyl ester 
• 193074-12-3 [2-({(S)-(3,5-dichloro-4-methoxyphenyl)-[2-(3-hydroxyphenyl)acetylamino]acetyl}methylamino)-(3S)-3-(4-fluoro-3-nitrophenyl)propionylamino]-(R)-(4-methoxyphenyl)acetic acid methyl ester 
• 193074-08-7 [2-({(R)-(3,5-dichloro-4-methoxyphenyl)-[2-(3-hydroxyphenyl)acetylamino]acetyl}methylamino)-(3S)-3-(4-fluoro-3-nitrophenyl)propionylamino]-(R)-(4-methoxyphenyl)acetic acid methyl ester 
• 100929-27-9 (R)-2-(Acetylamino)-2-(4-methoxyphenyl)ethanol 
• 100929-34-8 Acetic acid (R)-2-acetylamino-2-(4-methoxy-phenyl)-ethyl ester 
• 1159576-44-9 C₂₃H₃₄N₂O₇ 

Relevant academic research and scientific papers

An Auxiliary Approach for the Stereoselective Synthesis of Topologically Chiral Catenanes

Catenanes, molecules in which two rings are threaded through one another like links in a chain, can form as two structures related like an object and its mirror image but otherwise identical if the individual rings lack bilateral symmetry. These structure

Novel 2-[(benzylamino)methyl]pyrrolidine-3,4-diol derivatives as α-mannosidase inhibitors and with antitumor activities against hematological and solid malignancies

Novel α-mannosidase inhibitors of the type (2R,3R,4S)-2-({[(1R)-2-hydroxy-1-arylethyl]amino}methyl)pyrrolidine-3,4-diol have been prepared and assayed for their anticancer activities. Compound 30 with the aryl group = 4-trifluoromethylbiphenyl inhibits the proliferation of primary cells and cell lines of different origins, irrespective of Bcl-2 expression levels, inducing a G2/Mcell cycle arrest and by modification of genes involved in cell cycle progression and survival.

Derivatives of Dihydroxypyrrolidine as Anti-Cancer Compounds

The present invention relates to derivatives of dihydroxypyrrolidine useful in the treatment of cancer. The invention further relates to a process for making the compounds. The compounds are inhibitors of α mannosidase, and possibly, also inhibit nicotina

Synthesis of a model of chloropeptins I, II western subunit by the intramolecular S(N)Ar based methodology

Formation of a biaryl ether bond between the termini of a tetrapeptide containing a highly racemization prone amino acid by the intramolecular SNAr reaction afforded two diastereomeric 16-membered macrocycles along with their respective atropoisomers. The (R,S,R) and its atropoisomer constituted model of chloropeptins I, II, western part.

Stereoselective Aldol Reaction with Chiral Secondary Acetamides

The deprotonated acetamides 4a - c and 5a - c are added to prochiral carbonyl compounds.The influence of the solvent, of the reaction temperature, and of the enolate gegenion on the ratio of the isomeric products 8/9, 18/19, and 26/27, respectively, are studied.The highest degree of diastereoselectivity are observed, when the titanium enolate of the acetamide 4a or the threefold deprotonated N-acetyl-α-phenylglycinol (5a) is used.The diastereomers 18a - d, formed in excess in the addition of 5a to aldehydes, are isolated in pure from by a single recrystallization, and afford the enantiomerically pure β-hydroxy carboxylic acids 3a - d.Thereby, the chiral auxiliary, α-phenylglycinol (14), is recovered.