193074-08-7

Basic information

• Product Name: [2-({(R)-(3,5-dichloro-4-methoxyphenyl)-[2-(3-hydroxyphenyl)acetylamino]acetyl}methylamino)-(3S)-3-(4-fluoro-3-nitrophenyl)propionylamino]-(R)-(4-methoxyphenyl)acetic acid methyl ester
• Synonyms: [2-({(R)-(3,5-dichloro-4-methoxyphenyl)-[2-(3-hydroxyphenyl)acetylamino]acetyl}methylamino)-(3S)-3-(4-fluoro-3-nitrophenyl)propionylamino]-(R)-(4-methoxyphenyl)acetic acid methyl ester
• CAS NO: 193074-08-7
• Molecular Weight: 785.61
• Mol File: 193074-08-7.mol

Chemical Properties

• CAS DataBase Reference: [2-({(R)-(3,5-dichloro-4-methoxyphenyl)-[2-(3-hydroxyphenyl)acetylamino]acetyl}methylamino)-(3S)-3-(4-fluoro-3-nitrophenyl)propionylamino]-(R)-(4-methoxyphenyl)acetic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: [2-({(R)-(3,5-dichloro-4-methoxyphenyl)-[2-(3-hydroxyphenyl)acetylamino]acetyl}methylamino)-(3S)-3-(4-fluoro-3-nitrophenyl)propionylamino]-(R)-(4-methoxyphenyl)acetic acid methyl ester(193074-08-7)
• EPA Substance Registry System: [2-({(R)-(3,5-dichloro-4-methoxyphenyl)-[2-(3-hydroxyphenyl)acetylamino]acetyl}methylamino)-(3S)-3-(4-fluoro-3-nitrophenyl)propionylamino]-(R)-(4-methoxyphenyl)acetic acid methyl ester(193074-08-7)

Safety Data

• Hazardous Substances Data: 193074-08-7(Hazardous Substances Data)

Upstream product

• 193073-53-9 [(R)-(3,5-dichloro-4-methoxyphenyl)-(S)-(2-hydroxy-1-phenylethylamino)]acetic acid methyl ester 
• 193073-75-5 N-(tert-butoxycarbonyl)-(R)-(3,5-dichloro-4-methoxy)phenylglycine 
• 193073-58-4 (R)-Amino-(3,5-dichloro-4-methoxy-phenyl)-acetic acid methyl ester 
• 193074-02-1 [2-{(R)-[tert-butoxycarbonylamino-(3,5-dichloro-4-methoxyphenyl)acetyl]methylamino}-(3S)-3-(4-fluoro-3-nitrophenyl)propionylamino]-(R)-(4-methoxyphenyl)acetic acid methyl ester 
• 193073-96-0 [(2S)-2-(tert-butoxycarbonylmethylamino)-3-(4-fluoro-3-nitrophenyl)propionylamino]-(R)-(4-methoxyphenyl)methyl ester 
• 193073-99-3 [3-(4-fluoro-3-nitrophenyl)-(2S)-2-methylaminopropionylamino]-(R)-(4-methoxyphenyl)acetic acid methyl ester 
• 193073-48-2 (S)-N-(tert-butoxycarbonyl)-N-methyl-(S)-(4-fluoro-3-nitro)phenylalanine methyl ester 
• 193073-45-9 methyl 2-((tert-butoxycarbonyl)amino)-3-(4-fluoro-3-nitrophenyl)propanoate 
• 193073-38-0 (S)-N-(tert-butoxycarbonyl)-N-methyl-(S)-(4-fluoro-3-nitro)phenylalanine 
• 178744-39-3 L-4-fluoro-3-nitrophenylalanine methyl ester 
• 193073-85-7 methyl (R)-2-((tert-butoxycarbonyl)amino)-2-(4-methoxyphenyl)acetate 
• 15017-52-4 4-(bromomethyl)-1-fluoro-2-nitrobenzene 
• 78307-39-8 methyl 4-methoxyphenyl-D-phenylglycinate 
• 621-37-4 m-hydroxyphenylacetic acid 

Relevant articles and documents

Synthetic studies towards the synthesis of western and eastern chloropeptin I, II subunits

The western subunit (16-membered ring) was synthesized by the intramolecular SNAr reaction while the first 16-membered ring compound was obtained as a model of the eastern subunit via an intramolecular Ni0 mediated coupling reaction.

Synthesis of a model of chloropeptins I, II western subunit by the intramolecular S(N)Ar based methodology

Formation of a biaryl ether bond between the termini of a tetrapeptide containing a highly racemization prone amino acid by the intramolecular SNAr reaction afforded two diastereomeric 16-membered macrocycles along with their respective atropoisomers. The (R,S,R) and its atropoisomer constituted model of chloropeptins I, II, western part.