78312-00-2

Upstream product

• 555-16-8 4-nitrobenzaldehdye 
• 543-24-8 N-acetylglycine 
• 5356-71-8 1,3-diphenyl-1H-pyrazol-5-amine 

Downstream Products

• 1105064-86-5 6-(p-nitrobenzyl)-4-amino-3-mercapto-1,2,4-triazin-5-one 
• 1081844-77-0 (2E)-2-(acetylamino)-3-(4-nitrophenyl)prop-2-enoic acid 
• 1394856-45-1 1-(4-acetylphenyl)-4-(4-nitrobenzylidene)-2-methyl-1H-imidazol-5(4H)-one 
• 1394856-73-5 2-((1-(4-(2-methyl-4-(4-nitrobenzylidene)-5-oxo-4,5-dihydro-1H-imidazol-1-yl)phenyl)ethylidene)hydrazono)thiazolidin-4-one 
• 1394856-58-6 2-(1-(4-(2-methyl-4-(4-nitrobenzylidene)-5-oxo-4,5-dihydro-1H-imidazol-1-yl)phenyl)ethylidene)hydrazinecarbothioamide 
• 921195-97-3 (±)-2-ethoxy-3-(4'-aminophenyl)propionic acid 
• 921196-07-8 2-ethoxy-3-(4-nitrophenyl)acrylic acid 
• 515861-32-2 ethyl 2-ethoxy-3-(4-nitrophenyl)acrylate 
• 921195-92-8 (±)-2-methoxy-3-(4'-aminophenyl)propionic acid 
• 921196-05-6 2-methoxy-3-(4-nitrophenyl)acrylic acid 
• 103989-25-9 methyl 2-methoxy-3-(4-nitrophenyl)acrylate 
• 921195-99-5 (S)-2-ethoxy-3-(4-aminophenyl)propionic acid 
• 921195-98-4 (S)-2-ethoxy-3-(4-aminophenyl)propionic acid 
• 921195-93-9 (R)-(-)-3-(4-aminophenyl)-2-methoxypropionic acid 

Relevant academic research and scientific papers

Mechanistically Guided One Pot Synthesis of Phosphine-Phosphite and Its Implication in Asymmetric Hydrogenation

Although hybrid bidentate ligands are known to yield highly enantioselective products in asymmetric hydrogenation (AH), synthesis of these ligands is an arduous process. Herein, a one pot, atom-economic synthesis of a hybrid phosphine-phosphite (L1) is reported. After understanding the reactivity difference between an O-nucleophile versus C-nucleophile, one pot synthesis of Senphos (L1) was achieved (72 %). When L1 was treated with [Rh], 31P NMR revealed bidentate coordination to Rh. Senphos, in the presence of rhodium, catalyzes the AH of Methyl-2-acetamido-3-phenylacrylate and discloses an unprecedented turn over frequency of 2289, along with excellent enantio-selectivity (92 %). The generality is demonstrated by hydrogenating an array of alkenes. The AH operates under mild conditions of 1–2 bar H2 pressure, at room temperature. The practical relevance of L1 is demonstrated by scaling-up the reaction to 1 g and by synthesizing DOPA, a drug widely employed for the treatment of Parkinson's disease. Computational insights indicate that the R isomer is preferred by 3.8 kcal/mol over the S isomer.

Synthesis and preliminary biological evaluation of antibacterial and antifungal 5-arylidene tetramic acid-cadmium(II) complexes

The synthesis and biological evaluation of 5-arylidene-N-acetyl-tetramic acids cadmium(II) complexes are reported. Eleven novel compounds were prepared, characterized by nuclear magnetic resonance experiments and screened for their antimicrobial activity

Experimental and theoretical insights on the adsorption and inhibition mechanism of (2E)-2-(acetylamino)-3-(4-nitrophenyl) prop-2-enoic acid and 4-nitrobenzaldehyde on mild steel corrosion

Abstract: (2E)-2-(acetylamino)-3-(4-nitrophenyl)prop-2-enoic acid (NPP) was synthesized following a facile chemical method from 4-nitrobenzaldehyde (NB) and thoroughly characterized using spectroscopic techniques. These compounds were applied as novel inhibitors for corrosion of mild steel in 1M HCl using various methods such as absorbance difference, potentiodynamic polarization, and electrochemical impedance spectroscopy (EIS). The results indicate that these inhibitors show an excellent protection performance and achieve the corrosion inhibition efficiency values of 94percent and 84percent for NPP and NB, respectively. The adsorption of these molecules obeys the El-Awady isotherm model. The surface analysis of mild steel was investigated using scanning electron microscopy (SEM) and energy dispersive X-ray (EDX) methods. Furthermore, quantum chemical calculations were investigated using DFT method at B3LYP/6-31G (d,p) computed by Gaussian 09 showing a good correlation with the experimental results. Graphic abstract: [Figure not available: see fulltext.] Synopsis A novel corrosion inhibitor namely 4-nitrobenzaldehyde derivative NPP was prepared and analyzed for mild steel in 1M HCl. The analysis were conducted by electrochemical, surface supported by DFT based reactivity parameters. NPP functioned by adsorption obeying the El-Awady isotherm and produced a high efficiency of 94percent.

COMPOUNDS AND THEIR SALTS SPECIFIC TO THE PPAR RECEPTORS AND THE EGF RECEPTORS AND THEIR USE IN THE MEDICAL FIELD

The present invention relates to compounds comprising the general formula (I), in which R1 and R2, which may be identical or different, are selected from the group comprising —H or a linear or branched alkyl group having from 1 to 6 carbon atoms or togeth

Microwave-assisted synthesis and antimicrobial screening of new imidazole derivatives bearing 4-thiazolidinone nucleus

A new series of compounds 2-((1-(4-(4-arylidene-2-methyl-5-oxo-4,5-dihydro- 1H-imidazol-1-yl)phenyl)ethylidene)hydrazono)thiazolidin-4-ones (4a-o) have been synthesized under conventional and microwave irradiation method. All compounds were characterized by IR, 1H NMR, 13C NMR and mass spectra. Newly synthesized compounds were screened for their antibacterial and antifungal activities on Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Staphylococcus pyogenes, Candida albicans, Aspergillus niger and Aspergillus clavatus by bioassays, namely serial broth dilution. The synthesized compounds showed potent antimicrobial activity against tested microorganisms. Compounds 4h, 4j, 4m and 4n were the most potent amongst tested compounds.

Facile synthesis of 4-arylidene-5-imidazolinones as synthetic analogs of fluorescent protein chromophore

A facile and effective synthesis for a wide variety of 4-arylidene-5- imidazolinone derivatives was developed. 4-Arylidene-5-oxazolinones were prepared by Erlenmeyer azlactone synthesis from N-acylglycines and arylaldehydes. The ring-opening reactions of the 4-arylidene-5-oxazolinones with primary amines afforded 2-acylamino-3-arylacrylamides in excellent yields. A new dehydrative cyclization of the 2-acylamino-3-arylacrylamides in pyridine under reflux furnished the corresponding 4-arylidene-5-imidazolinones in good yields.

Synthesis of 5H-dibenzo (b,f) azepine-5-{4-substitutedbenzylidene-2- methylimidazole-5-one}-carboxamides and their antioxidant activity

A series of 5H-dibenzo (b,f) azepine-5-{4-substitutedbenzylidene-2- methylimidazole5-one}-carboxamides were synthesized and characterized on the basis of IR, 1H NMR, .and mass spectral (MS) data. The title compounds were subjected to in-vitro antioxidant testing using DPPH method. Some of the compounds showed significant antioxidant activity when compared with standard ascorbic acid.

New and convenient route for the synthesis of some new pyrazol-5-yl-1H- imidazole derivatives

A simple and efficient method for the synthesis of some new pyrazol-5-yl-1H-imidazoles 4a-h is described. In this method oxazolones 5a-h were produced as minor products. The X-ray analysis confirmed the structures of 4 and 5. The Japan Institute of Heterocyclic Chemistry.

Compounds and Their Salts Specific to the PPAR Receptors and the EGF Receptors and Their Use in the Medical Field

The present invention relates to compounds comprising the general formula (I), in which R1 and R2, which may be identical or different, are selected from the group comprising —H or a linear or branched alkyl group having from 1 to 6

Solid support Erlenmeyer synthesis of azlactones using microwaves

A rapid and efficient protocol for the synthesis of azlactones is reported starting from acetyl/benzoylglycine and various aromatic aldehydes in the presence of acetic anhydride and sodium acetate in dry media using silica gel as solid support under microwave irradiation. The mild conditions, excellent yields, high purity. short reaction time and easy work-up are some of the major advantages of this method.