78318-01-1Relevant articles and documents
Transition-metal chloride mediated addition reaction of diorganomagnesium to easily enolizable ketones
Sada, Mutsumi,Matsubara, Seijiro
, p. 2612 - 2616 (2011)
An alkylation to an easily enolizable ketone, such as β-tetralone, is difficult to perform with Grignard reagent (RMgX) or with diorganomagnesium (R2Mg), because a deprotonation to form a magnesium enolate occurs predominantly. To avoid the prior enolization, a complex reagent of a transition-metal salt and R2Mg was examined: A combination of R 2Mg with iron(II) chloride (FeCl2) or ytterbium(III) chloride (YbCl3) gave a complex reagent that can realize a nucleophilic reaction to β-tetralone prior to the enolization. A combination of RMgX with these metal salts is inferior to a combination of R2Mg with them to obtain the nucleophilic complex reagent.
Chemotherapeutic agents
-
, (2008/06/13)
A method of treating or preventing viral infections, in particular rhinovirus infections comprising the administration of an effective amount of a 2-phenyltetralin derivative or a heterocyclic analogue thereof. Pharmaceutical compositions containing these compounds, and some novel compounds are also disclosed.
STRUCTURE OF THE INTERMEDIATE FORMED IN THE REACTION OF THE STYRENE RADICAL CATION AND NEUTRAL STYRENE.
Groenewold,Chess,Gross
, p. 539 - 543 (2007/10/02)
The structure of the ion-molecule adduct produced in the gas-phase reaction of the styrene radical cation with neutral styrene has been probed by collisionally stabilizing the adduct and then acquiring its collision-activated decomposition (CAD) spectrum with a tandem mass spectrometer. The CAD spectrum of the adduct is nearly identical with the CAD spectra of the cis- and trans-diphenylcyclobutane radical cations and with the product ion resulting from a 1,4-regiospecific water elimination from the 1,4-diphenylbutan-1-ol radical cation; therefore the radical cations from all four precursors possess the same structure. The DELTA H//f of this radical cation is shown to be less than equivalent to 239 kal/mol; therefore it cannot have the trans-1,2-diphenylcyclobutane structure ( DELTA H//f equals 247 kcal/mol). The results support a two-step mechanism for the left bracket 1 plus 2 right bracket cycloaddition reaction.