78318-44-2 Usage
General Description
Ethyl 4-methyl-2-morpholinopyrimidine-5-carboxylate is a chemical compound with the molecular formula C12H17N3O3. It is a white solid that is commonly used as a building block in the synthesis of pharmaceutical compounds. This chemical is known for its potential use as an antihypertensive agent and has been studied for its potential therapeutic effects on hypertension and other cardiovascular disorders. Its structure contains a morpholine ring and a pyrimidine ring, making it a versatile compound for medicinal chemistry research. Additionally, it is important to handle this compound with care and according to safety protocols due to its potential hazardous and toxic effects.
Check Digit Verification of cas no
The CAS Registry Mumber 78318-44-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,8,3,1 and 8 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 78318-44:
(7*7)+(6*8)+(5*3)+(4*1)+(3*8)+(2*4)+(1*4)=152
152 % 10 = 2
So 78318-44-2 is a valid CAS Registry Number.
78318-44-2Relevant articles and documents
Optimisation of pharmacokinetic properties in a neutral series of 11β-HSD1 inhibitors
Scott, James S.,Gill, Adrian L.,Godfrey, Linda,Groombridge, Sam D.,Rees, Amanda,Revill, John,Schofield, Paul,S?rme, Pernilla,Stocker, Andrew,Swales, John G.,Whittamore, Paul R.O.
, p. 6756 - 6761 (2013/01/14)
11β-HSD1 is increasingly seen as an attractive target for the treatment of type II diabetes and other elements of the metabolic syndrome. In this program of work we describe how a series of neutral 2-thioalkyl-pyridine 11β-HSD1 inhibitors were optimized in terms of their pharmacokinetic properties to give compounds with excellent bioavailability in both rat and dog through a core change to pyrimidine. A potential reactive metabolite issue with 4-thioalkyl-pyrimidines was circumvented by a switch from sulfur to carbon substitution.
