78329-47-2

Basic information

• Product Name: 5-Chloro-1-(phenylsulfonyl)indole
• Synonyms: 5-Chloro-1-(phenylsulfonyl)indole
• CAS NO: 78329-47-2
• Molecular Formula: C₁₄H₁₀ClNO₂S
• Molecular Weight: 291.7527
• Mol File: 78329-47-2.mol
• Article Data: 17

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-Chloro-1-(phenylsulfonyl)indole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Chloro-1-(phenylsulfonyl)indole(78329-47-2)
• EPA Substance Registry System: 5-Chloro-1-(phenylsulfonyl)indole(78329-47-2)

Safety Data

• Hazardous Substances Data: 78329-47-2(Hazardous Substances Data)

Upstream product

• 1073-69-4 N-4-chlorophenylhydrazine 
• 98-09-9 benzenesulfonyl chloride 
• 17422-32-1 5-chloro-1H-indole 

Downstream Products

• 1394431-60-7 lithium 5-chloro-1-(phenylsulfonyl)-1H-indole-2-sulfinate 
• 1394431-61-8 N-(4-bromobenzyl)-5-chloro-1-(phenylsulfonyl)-1H-indole-2-sulfonamide 
• 1394431-63-0 5-chloro-N-((2',4'-difluorobiphenyl-4-yl)methyl)-1H-indole-2-sulfonamide 
• 1394431-80-1 5-chloro-N-((4'-(methylsulfonyl)biphenyl-4-yl)methyl)-1H-indole-2-sulfonamide 
• 1394431-69-6 5-chloro-N-((3,4'-difluorobiphenyl-4-yl)methyl)-1H-indole-2-sulfonamide 
• 1388032-50-5 5-chloro-2-iodo-1H-indole 

Relevant articles and documents

Construction of Oxepino[3,2-b]indoles via [4+3] Annulation of 2-Ylideneoxindoles with Crotonate-Derived Sulfur Ylides

A [4+3] annulation of 2-ylideneoxindoles with crotonate-derived sulfur ylides has been developed. A series of oxepino[3,2-b]indoles were prepared in moderate to excellent yields (62-93%) under mild conditions. Moreover, the synthetic oxepino[3,2-b] indoles can be further transformed into more complex cyclopropa[5,6]oxepino[3,2-b]indoles via a [2+1] cyclopropanation. In addition, the synthetic compounds show certain antiproliferative activity against K562 and MCF-7 cells, and its IC50 values for these two kinds of tumor cells up to 5.40±0.88 μM and 18.41±0.50 μM, respectively. (Figure presented.).

Highly diastereoselective synthesis of cyclopropane-fused spiro-pseudoindoxyl derivatives through [2 + 1] annulation of 2-ylideneoxindoles and sulfonium bromides

Compared with the intensively studied C3 spirooxindoles, limited reliable approaches are reported for synthesizing structurally analogous C2-spiropseudoindoxyl derivatives. Here, we developed an efficient method for highly diastereoselective synthesis of

MAP4K4 (HGK) Inhibitors

The invention provides mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4) inhibitors, and pharmaceutically acceptable salts, hydrides and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof with an effective amount of the compound or composition, and detecting a resultant diminution of tumor cell growth, cancer or metastasis.