783321-45-9Relevant academic research and scientific papers
Chemoenzymatic syntheses of (R)-2-bromo-, (R)2-chloro- and (R)2-azido-1-(1,3-benzodioxol-5-yl)-1-ethanol
Antunes, Heidi,Fardelone, Lucidio C.,Rodrigues, J. Augusto R.,Moran, Paulo J.S.
, p. 2615 - 2620 (2004)
Enantioselective reductions of 2-X-1-(1,3-benzodioxol-5-yl)-1-ethanones, (X = Cl, Br, N3) by Rhodothorula glutinis CCT 2182 afforded the corresponding (R)-ethanols in good to excellent yields (57-99%) and excellent enantiomeric excesses (>99%). These alcohols may be used as raw materials for the preparation of the pharmaceuticals (R)-(-)-epinephrine, (R)-(-)-norepinephrine and (R)-(-)-isoproterenol.
DIAMINOTHIAZOLES
-
Page/Page column 94-95, (2010/02/05)
The present invention is directed to novel diaminothiazoles of formula These compounds inhibit cyclin-dependent kinase 4 (Cdk4) and are selective against Cdk2 and Cdk1. These compounds and their pharmaceutically acceptable salts and esters have antiproliferative activity and are useful in the treatment or control of cancer, in particular solid tumors. This invention is also directed to pharmaceutical compositions containing such compounds and to methods of treating or controlling cancer, most particularly the treatment 6r control of breast, lung and colon and prostate tumors.
