83070-15-9

Upstream product

• 23342-96-3 1-(benzo[d][1,3]dioxol-5-yl)-2-diazoethan-1-one 
• 3162-29-6 1-(benzo[d][1,3]dioxol-6-yl)ethanone 
• 94-53-1 Piperonylic acid 
• 25054-53-9 3,4-(methylenedioxy)benzoyl chloride 

Downstream Products

• 313216-50-1 (S)-1-(3,4-methylenedioxyphenyl)-2-chloroethanol 
• 313216-50-1 (R)-1-(1,3-benzodioxol-5-yl)-2-chloro-1-ethanol 
• 783321-45-9 1-(benzo[d][1,3]dioxol-5-yl)-2,2-dibromoethan-1-one 
• 40288-65-1 1-(benzo[1,3]dioxol-5-yl)-2-bromoethanone 
• 109772-83-0 2-Benzo[1,3]dioxol-5-yl-2-hydroxy-3-(3,4,5-trimethoxy-phenoxy)-propionitrile 

Relevant academic research and scientific papers

NEW ARYLALKENYLPROPARGYLAMINE DERIVATIVES EXHIBITING NEUROPROTECTIVE ACTION FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES

The invention relates to novel arylalkenylpropargylamine derivatives of general formula (I) or enantiomers or diastereomers thereof or salts, optionally pharmaceutically acceptable salts, or solvates of any of these. The compounds can be used in treating or preventing a disease or condition in a mammal related to monoamine oxidase dysfunction, especially in neurodegenerative diseases, e.g. Parkinson's disease, Alzheimer's disease or Huntington's disease.

Chemoenzymatic syntheses of (R)-2-bromo-, (R)2-chloro- and (R)2-azido-1-(1,3-benzodioxol-5-yl)-1-ethanol

Enantioselective reductions of 2-X-1-(1,3-benzodioxol-5-yl)-1-ethanones, (X = Cl, Br, N3) by Rhodothorula glutinis CCT 2182 afforded the corresponding (R)-ethanols in good to excellent yields (57-99%) and excellent enantiomeric excesses (>99%). These alcohols may be used as raw materials for the preparation of the pharmaceuticals (R)-(-)-epinephrine, (R)-(-)-norepinephrine and (R)-(-)-isoproterenol.

On Odoratin

Two new syntheses of odoratin (1) are reported.