78348-97-7Relevant academic research and scientific papers
Dibasic biphenyl H3 receptor antagonists: Steric tolerance for a lipophilic side chain
Bordi, Fabrizio,Rivara, Silvia,Dallaturca, Elisa,Carmi, Caterina,Pala, Daniele,Lodola, Alessio,Vacondio, Federica,Flammini, Lisa,Bertoni, Simona,Ballabeni, Vigilio,Barocelli, Elisabetta,Mor, Marco
experimental part, p. 214 - 230 (2012/03/26)
Within a series of histamine H3-antagonists characterized by a biphenyl core and two basic groups, we identified (S)-1-{[4′-((2- methylpyrrolidin-1-yl)methyl)biphenyl-4-yl]methyl}piperidine as a lead scaffold to introduce an additional lipophil
Selectivities in the Reactions of Alkyl-, Aryl- and Heterosubstituted Organotitanium Compounds
Weidmann, Beat,Widler, Leo,Olivero, Alan G.,Maycock, Christopher D.,Seebach, Dieter
, p. 357 - 361 (2007/10/02)
Solutions of the title compounds R-Ti(OR')3 (1) are generally available from organolithium (or magnesium) derivatives according to equation 1.It is shown (table 1) that some heterosubstituted organotitanium compounds are more stable thermally than their lithium counterparts.The reagents 1 are highly selective carbonylophiles (Tables 1 and 2), their reactivity can be modified by variation of the R'O-group (Table 3) and with the chiral (S)-2-methyl-1-butoxy group an enantioselective addition can be achieved.
