78358-49-3

Upstream product

• 75-03-6 ethyl iodide 
• 78358-45-9 (5R,6S)-6-((S)-1-Hydroxy-ethyl)-3-mercapto-7-oxo-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitro-benzyl ester 

Downstream Products

• 78359-02-1 p-nitrobenzyl (5R)-6-<(Z)-ethylidene>-3-ethylthio-7-oxo-1-azabicyclo<3.2.0>hept-2-ene-2-carboxylate 
• 105076-10-6 p-nitrobenzyl (4'S,5R,6S)-3-ethylthio-4'-methyl-7-oxo-1-azabicyclo<3.2.0>hept-2-ene-6-spiro-5'-(4',5'-dihydro-3'H-pyrazole)-2-carboxylate 
• 105076-10-6 p-nitrobenzyl (4'R,5R,6R)-3-ethylthio-4'-methyl-7-oxo-1-azabicyclo<3.2.0>hept-2-ene-6-spiro-5'-(4',5'-dihydro-3'H-pyrazole)-2-carboxylate 
• 105076-13-9 p-nitrobenzyl (5R)-3-ethylthio-6-isopropylidene-7-oxo-1-azabicyclo<3.2.0>hept-2-ene-2-carboxylate 

Relevant academic research and scientific papers

Reaction of Olivanic Acids with Hypobromous Acid: The Preparation and Use of a Versatile Intermediate, the C-3 Thiol

The 3-(E)-2-acetamidoethenylthio-substituent of olivanic acid derivatives reacts with hypobromous acid to afford a C-3 thiol which undergoes alkylation reactions and addition to propiolates.