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Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
(+/-)-trans-2-(Trifluoromethyl)cyclopropanecarboxylic acid is utilized as a building block in the synthesis of various pharmaceutical and agrochemical compounds. Its unique structure and properties make it a valuable component in the development of new drugs and pesticides.
Used as a Reagent in Organic Chemistry:
In the field of organic chemistry, (+/-)-trans-2-(Trifluoromethyl)cyclopropanecarboxylic acid serves as a reagent in reactions such as the formation of esters and amides. Its reactivity and functional group compatibility contribute to its use in these processes.
Used in Biological Activity Research:
(+/-)-trans-2-(Trifluoromethyl)cyclopropanecarboxylic acid has been studied for its potential biological activities, including antifungal and antibacterial properties. This research explores its applications in medicine and other fields where such properties could be beneficial.

Upstream product

• 94633-26-8 ethyl 5,5,5-trifluoro-4-tosyloxyvalerate 
• 70961-05-6 4-trifluoromethyl-4-oxobutyric acid ethyl ester 
• 94633-25-7 ethyl 5,5,5-trifluoro-4-oxo-3-ethoxycarbonyl-pentanoate 
• 70961-06-7 ethyl 4-hydroxy-5,5,5-trifluoropentanoate 

Downstream Products

• 22591-41-9 Toluene-4-sulfonic acid (1R,2R)-2-trifluoromethyl-cyclopropylmethyl ester 
• 22666-34-8 trans-2-trifluoromethylcyclopropylmethanol 

Relevant academic research and scientific papers

Fluoroalkyl-substituted cyclopropane derivatives: Synthesis and physicochemical properties

A series of all 12 cis- and trans-cyclopropanecarboxylic acids and cyclopropylamines bearing CH2F, CHF2, and CF3 substituents were synthesized by different methods on a multigram scale. Dissociation constants (pKa) and log P values were measured for the o

(2R,1'S,2'R)- And (2S,1'S,2'R)-3-[2-mono(di,tri)fluoromethylcyclopropyl] alanines and their incorporation into hormaomycin analogues

Efficient and scalable syntheses of enantiomerically pure (2 R ,1' S ,2' R )- and (2 S ,1' S ,2' R )-3-[2-mono(di,tri)fluoromethylcyclopropyl] alanines 9a - c , as well as allo-D-threonine ( 4 ) and ( 2 S,3R)-β-methylphenylalanine (3), using the Belokon' approach with (S )- and (R )-2-[( N-benzylprolyl)amino]benzophenone [(S)- and (R)-10 ] as reusable chiral auxiliaries have been developed. Three new fluoromethyl analogues of the naturally occurring octadepsipeptide hormaomycin ( 1 ) with (fluoromethylcyclopropyl) alanine moieties have been synthesized and subjected to preliminary tests of their antibiotic activity.

An efficient and safe method for the multigram synthesis of trans -2-(trifluoromethyl)cyclopropylamine

trans-2-(Trifluoromethyl)cyclopropylamine was prepared on a multigram scale from readily accessible 4,4,4-trifluorobut-2-enoic acid in five steps. The key step was a high-yielding cyclopropane ring formation from 4,4,4-trifluorobut-2- enoic acid methoxymethyl amide under Corey-Chaykovsky reaction conditions. Georg Thieme Verlag Stuttgart New York.

Iron-catalyzed preparation of trifluoromethyl substituted vinyl- and alkynylcyclopropanes

A convenient iron-catalyzed procedure to prepare trifluoromethylated vinyl- and alkynylcyclopropanes in a chemo- and diastereoselective manner is presented. The active diazo compound (trifluoromethyl diazomethane) is generated in situ and used in the conc

Regioselectivity in the Ring Opening of 2-Alkylcyclopropylmethyl Radicals: the Effect of Electronegative Substituents

The regioselectivity of the ring-opening of the trans-2-alkylcyclopropylmethyl radical A to give the primary alkyl radicals B, or the secondary alkyl radicals C, has been investigated, where the groups R and/or CXY carry electronegative substituents.All these reactions gave principally the secondary alkyl radicals C, whereas, in the absence of electronegative substituents, ring-opening occurs in favour of the primary alkyl radicals B.This regioselectivity is interpreted in terms of the frontier orbital interactions which are involved.