78397-39-4

Usage

Uses

Used in Pharmaceutical Industry:
Boc-L-Ornithine methyl ester is used as a building block for the synthesis of bioactive peptides and pharmaceutical compounds. Its Boc protection allows for selective modifications, while the methyl ester group enables further derivatization, making it suitable for the development of therapeutic agents with specific biological activities.
Used in Organic Synthesis:
In the field of organic synthesis, Boc-L-Ornithine methyl ester is used as a versatile intermediate for the preparation of various organic compounds. Its protected amine and ester functional groups provide opportunities for selective reactions and the synthesis of complex molecular structures.
Used in Peptide Chemistry:
Boc-L-Ornithine methyl ester is utilized as a key component in peptide chemistry for the assembly of peptide sequences. Its Boc protection ensures the selective formation of peptide bonds, while the methyl ester group allows for the incorporation of the molecule into larger peptide structures or the attachment of additional functional groups.
Used in Research and Development:
In research and development, Boc-L-Ornithine methyl ester is employed as a starting material for the exploration of new chemical reactions and the synthesis of novel compounds with potential applications in various fields, including medicine, agriculture, and materials science. Its unique structural features make it an attractive candidate for the design and synthesis of innovative molecules with specific properties and functions.

Upstream product

• 24608-52-4 tert-butyl chloroformate 
• 5874-75-9 methyl (2S)-2-amino-5-[[(benzyloxy)carbonyl]amino]pentanoate hydrochloride 
• 67-56-1 methanol 
• 21887-64-9 N₂-(tert-butoxycarbonyl)-L-ornithine 
• 2480-95-7 methyl (S)-5-(((benzyloxy)carbonyl)amino)-2-((tertbutoxycarbonyl)amino)pentanoate 

Downstream Products

• 1440433-94-2 (S,E)-2-((tert-butoxycarbonyl)amino)-5-(3-(3,4-dihydroxyphenyl)acrylamido)pentanoic acid 
• 1440434-04-7 C₂₄H₃₂N₂O₉ 
• 21887-64-9 N₂-(tert-butoxycarbonyl)-L-ornithine 
• 114200-46-3 3(S)-amino>-2-oxopiperidine 
• 42538-31-8 (3S)-3-aminopiperidin-2-one hydrochloride 

Relevant academic research and scientific papers

Caffeic acid derivatives: A new type of influenza neuraminidase inhibitors

Recently, many natural products, especially some plant-derived polyphenols have been found to exert antiviral effects against influenza virus and show inhibitory activities on neuraminidases (NAs). In our research, we took caffeic acid which contained two phenolic hydroxyl groups as the basic fragment to build a small compound library with various structures. The enzyme inhibition result indicated that some compounds exhibited moderate activities against NA and compound 15d was the best with IC50 = 7.2 μM and 8.5 μM against N2 and N1 NAs, respectively. The 3,4-dihydroxyphenyl group from caffeic acid was important for the activity according to the docking analysis. Besides, compound 15d was found to be a non-competitive inhibitor with Ki = 11.5 ± 0.25 μM by the kinetic study and also presented anti-influenza virus activity in chicken embryo fibroblast cells. It seemed promising to discover more potent NA inhibitors from caffeic acid derivatives to cope with influenza virus.

Inhibitors of N α-acetyl-l-ornithine deacetylase: Synthesis, characterization and analysis of their inhibitory potency

A series of N α-acyl (alkyl)- and N α- alkoxycarbonyl-derivatives of l- and d-ornithine were prepared, characterized, and analyzed for their potency toward the bacterial enzyme N α-acetyl-l-ornithine deacetylase (ArgE). Ar

Ceric ammonium nitrate (CAN) mediated esterification of N-Boc amino acids allows either retention or removal of the N-Boc group

Reaction of N-Boc amino acids with ceric ammonium nitrate in an alcohol as the solvent at room temperature resulted in the esterification of N-Boc amino acids with Boc group retention. When the reaction was conducted at reflux temperature, esterification was accompanied with simultaneous removal of the Boc group. Both reactions gave the desired products in good yields.

Dopamine Receptor Modulation by Conformationally Constrained Analogues of Pro-Leu-Gly-NH2

Two series of conformationally constrained analogues of Pro-Leu-Gly-NH2 (PLG) have been synthesized.In one series of analogues, the Leu-Gly-NH2 dipeptide segment of PLG was replaced with the γ-lactam residues 3(S)- and 3(R)-amino-2-oxopyrrolidineacetamide