784-94-1

Basic information

• Product Name: 4-AMINO-N-METHYL-N-PHENYL-BENZAMIDE
• Synonyms: 4-AMINO-N-METHYL-N-PHENYL-BENZAMIDE
• CAS NO: 784-94-1
• Molecular Formula: C₁₄H₁₄N₂O
• Molecular Weight: 226.27
• Mol File: 784-94-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 418.6±37.0 °C(Predicted)
• Appearance: /
• Density: 1.196±0.06 g/cm3(Predicted)
• PKA: 2.23±0.10(Predicted)
• CAS DataBase Reference: 4-AMINO-N-METHYL-N-PHENYL-BENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-AMINO-N-METHYL-N-PHENYL-BENZAMIDE(784-94-1)
• EPA Substance Registry System: 4-AMINO-N-METHYL-N-PHENYL-BENZAMIDE(784-94-1)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 784-94-1(Hazardous Substances Data)

Usage

General Description

4-AMINO-N-METHYL-N-PHENYL-BENZAMIDE is a chemical compound with the molecular formula C14H14N2O. It is an amide derivative of benzamide and contains a benzene ring with an amino group, a methyl group, and a phenyl group attached. 4-AMINO-N-METHYL-N-PHENYL-BENZAMIDE is used in pharmaceutical research and can act as an inhibitor for the enzyme 11-beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1), which is involved in the conversion of inactive cortisone to active cortisol. Additionally, it has potential applications in the development of drugs for the treatment of metabolic disorders and inflammatory diseases. However, it may also have potential risks and hazards associated with its handling and use, so proper safety precautions should be taken when working with this chemical.

Upstream product

• 961-61-5 N-methyl-N-phenyl-4-nitrobenzamide 
• 122-04-3 4-nitro-benzoyl chloride 
• 62-23-7 4-nitro-benzoic acid 
• 100-61-8 N-methylaniline 

Downstream Products

• 109547-33-3 [4-(Methyl-phenyl-carbamoyl)-phenylamino]-acetic acid ethyl ester 
• 389601-08-5 N-[4-(N-methyl-N-phenylaminocarbonyl)-phenylmethyl]-3-(4'-trifluoromethylbiphenyl-2-carbonylamino)-benzoic acid amide 
• 389601-10-9 N-[4-(N-methyl-N-phenylaminocarbonyl)-phenylmethyl]-3-(biphenyl-2-carbonylamino)-benzoic acid amide 
• 941423-63-8 C₂₁H₁₇IN₂O₂ 
• 713507-72-3 C₂₁H₁₇N₃O₄ 
• 1382354-35-9 methyl 2-{4-(methylphenylcarbamoyl)phenylamino}benzoate 
• 1382354-39-3 C₂₁H₁₈N₂O₃ 
• 1382353-95-8 4-(2-carbamoylphenylamino)-N-methyl-N-phenylbenzamide 
• 1646189-19-6 N-phenyl-N-methyl-p-(benzylamino)benzamide 
• 1477586-03-0 N-phenyl-N-methyl-ap-(methylamino)benzamide 
• 55198-73-7 N-phenyl-N-methyl-p-(N',N'-dimethylamino)benzamide 
• 1646189-20-9 N-phenyl-N-methyl-p-(phenylamino)benzamide 
• 5100-28-7 N-phenyl-N-methyl-p-(ethoxycarbonylamino)benzamide 
• 183491-70-5 4-(4'-methylbiphenyl-2-carboxamido)-N-methyl-N-phenylbenzamide 

Relevant articles and documents

Hypervalent iodine(III)-mediated oxidative dearomatizing cyclization of arylamines

An oxidative dearomatizing cyclization of arylamines promoted by iodobenzene bis(trifluoroacetate) [PhI(CF3CO2) 2] has been explored, leading to a novel synthetic approach to functionalized spirocyclic building blocks containing the structurally unique dieniminium moiety. This unprecedented methodology, featuring oxidative dearomatization and carbon-carbon bond-forming cyclization, to some extent, not only expands the synthetic potential of hypervalent iodine chemistry, but also enriches the oxidation chemistry of arylamines.

Conformational studies of tertiary oligo-m-benzanilides and oligo-p-benzanilides in solution

A series of oligo-m- and p-benzanilides were made and their conformations in solution were studied by NMR. In most cases, conformational mixtures were observed as soon as three or more monomers were incorporated into the oligomer. Some crystal structures were obtained, which indicated that helical conformations were adopted in the solid state.