784-94-1

Usage

Uses

Used in Pharmaceutical Research:
4-AMINO-N-METHYL-N-PHENYL-BENZAMIDE is used as an inhibitor for the enzyme 11-beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1), which is involved in the conversion of inactive cortisone to active cortisol. This makes it a potential candidate for the development of drugs targeting metabolic disorders and inflammatory diseases.
Used in Drug Development:
4-AMINO-N-METHYL-N-PHENYL-BENZAMIDE has potential applications in the development of drugs for the treatment of metabolic disorders and inflammatory diseases due to its inhibitory effect on the enzyme 11β-HSD1. This could lead to the creation of new therapeutic options for patients suffering from these conditions.
Safety Precautions:

Upstream product

• 961-61-5 N-methyl-N-phenyl-4-nitrobenzamide 
• 122-04-3 4-nitro-benzoyl chloride 
• 62-23-7 4-nitro-benzoic acid 
• 100-61-8 N-methylaniline 

Downstream Products

• 109547-33-3 [4-(Methyl-phenyl-carbamoyl)-phenylamino]-acetic acid ethyl ester 
• 183491-70-5 4-(4'-methylbiphenyl-2-carboxamido)-N-methyl-N-phenylbenzamide 
• 941423-63-8 C₂₁H₁₇IN₂O₂ 
• 713507-72-3 C₂₁H₁₇N₃O₄ 
• 1382354-35-9 methyl 2-{4-(methylphenylcarbamoyl)phenylamino}benzoate 
• 1382354-39-3 C₂₁H₁₈N₂O₃ 
• 1382353-95-8 4-(2-carbamoylphenylamino)-N-methyl-N-phenylbenzamide 
• 1646189-19-6 N-phenyl-N-methyl-p-(benzylamino)benzamide 
• 1477586-03-0 N-phenyl-N-methyl-ap-(methylamino)benzamide 
• 55198-73-7 N-phenyl-N-methyl-p-(N',N'-dimethylamino)benzamide 
• 1646189-20-9 N-phenyl-N-methyl-p-(phenylamino)benzamide 
• 5100-28-7 N-phenyl-N-methyl-p-(ethoxycarbonylamino)benzamide 
• 389601-10-9 N-[4-(N-methyl-N-phenylaminocarbonyl)-phenylmethyl]-3-(biphenyl-2-carbonylamino)-benzoic acid amide 
• 389601-08-5 N-[4-(N-methyl-N-phenylaminocarbonyl)-phenylmethyl]-3-(4'-trifluoromethylbiphenyl-2-carbonylamino)-benzoic acid amide 

Relevant academic research and scientific papers

Hypervalent iodine(III)-mediated oxidative dearomatizing cyclization of arylamines

An oxidative dearomatizing cyclization of arylamines promoted by iodobenzene bis(trifluoroacetate) [PhI(CF3CO2) 2] has been explored, leading to a novel synthetic approach to functionalized spirocyclic building blocks containing the structurally unique dieniminium moiety. This unprecedented methodology, featuring oxidative dearomatization and carbon-carbon bond-forming cyclization, to some extent, not only expands the synthetic potential of hypervalent iodine chemistry, but also enriches the oxidation chemistry of arylamines.

Design, synthesis, and biological activity of a novel series of human sirtuin-2-selective inhibitors

Selective inhibitors of human sirtuin 2 (SIRT2), a deacetylase, are candidate therapeutic agents for neurodegenerative diseases such as Parkinson's disease and Huntington's disease as well as potential tools for elucidating the biological functions of SIRT2. On the basis of homology models of SIRT1 and SIRT2, we designed and prepared a series of 2-anilinobenzamide analogues. Enzyme assays using recombinant SIRT1 and SIRT2 revealed that 3'-phenethyloxy-2- anilinobenzamide analogues such as 33a and 33i are potent and selective SIRT2 inhibitors, showing more than 3.5-fold greater SIRT2-inhibitory activity and more than 35-fold greater SIRT2-selectivity compared with AGK2 (3), a previously reported SIRT2-selective inhibitor. Compound 33a also induced a dose-dependent selective increase of α-tubulin acetylation in human colon cancer HCT116 cells, indicating selective inhibition of SIRT2 in the cells. These 3'-phenethyloxy-2-anilinobenzamide derivatives represent an entry into a new class of SIRT2-selective inhibitors.

Conformational studies of tertiary oligo-m-benzanilides and oligo-p-benzanilides in solution

A series of oligo-m- and p-benzanilides were made and their conformations in solution were studied by NMR. In most cases, conformational mixtures were observed as soon as three or more monomers were incorporated into the oligomer. Some crystal structures were obtained, which indicated that helical conformations were adopted in the solid state.