784105-33-5

Basic information

• Product Name: alpha-aMine-oMega-propionic acid triethylene glycol
• Synonyms: alpha-aMine-oMega-propionic acid triethylene glycol;H2N-PEG3-CH2CH2COOH;3-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)propanoic acid;α-AMine-ω-propionic acid triethylene glycol;NH2-PEG3-COOH;Amino-PEG3-propionic acid;H2N-PEG3-CH2CH2COOH
• CAS NO: 784105-33-5
• Molecular Formula: C9H19NO5
• Molecular Weight: 221.25086
• Product Categories: PEG-COOH
• Mol File: 784105-33-5.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 372.1±32.0 °C(Predicted)
• Appearance: /
• Density: 1.137±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 4.27±0.10(Predicted)
• CAS DataBase Reference: alpha-aMine-oMega-propionic acid triethylene glycol(CAS DataBase Reference)
• NIST Chemistry Reference: alpha-aMine-oMega-propionic acid triethylene glycol(784105-33-5)
• EPA Substance Registry System: alpha-aMine-oMega-propionic acid triethylene glycol(784105-33-5)

Safety Data

• Hazardous Substances Data: 784105-33-5(Hazardous Substances Data)

Usage

Description

Amino-PEG3-acid is a PEG reagent containing an amino (NH2) and a terminal carboxylic acid group. The hydrophilic PEG unit increases hydrophilicity. NH2 amine group is reactive with carboxylic acids in the presence of coupling reagent such as EDC , or directly with NHS esters, to form a stable amide bond.

Uses

3-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)propanoic Acid is a building block that has been used as a reactant for the preparation of a MUC1-glycopeptide-BSA conjugate vaccine bearing (deoxy)(fluoro)-Thomsen-Friedenreich antigen.

Upstream product

• 252881-74-6 tert-butyl 3-(2-(2-(2-aminoethoxyl)ethoxy)ethoxy)propanoate 
• 1349193-22-1 8-dibenzylamino-3,6-dioxaoctan-1-ol 

Downstream Products

• 2055353-75-6 C₁₆H₂₄N₂O₈ 
• 1612221-29-0 benzyl 3-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)propanoate 

Relevant articles and documents

Preparation method of amino polyethylene glycol propionic acid

The invention relates to the field of organic synthesis, in particular to a preparation method of amino polyethylene glycol propionic acid. The preparation method comprises the steps that catalytic hydrogenation is carried out on dibenzyl amino polyethylene glycol tert-butyl propionate shown in formula I-2 to obtain amino polyethylene glycol tert-butyl propionate shown in formula I-3; (2) the amino polyethylene glycol tert-butyl propionate shown in formula I-3 is hydrolyzed under the acidic condition to obtain amino polyethylene glycol propionic acid shown in formula I. The preparation methodof the amino polyethylene glycol propionic acid has the advantages that the defects in the prior art that the yield is low, the dangerousness is high, and the enlargement of production is difficult are overcome, the reaction conditions are mild, the operation is simple, an intermediate does not to be purified, the next reaction can be directly carried out, the whole yield reaches up to 87-92%, thepurity of end products reaches up to 97-99.5%, and a safe and efficient synthetic route is provided for the preparation of amino polyethylene glycol propionic acid.