784143-05-1Relevant academic research and scientific papers
Discovery of a novel class of biphenyl pyrazole sodium channel blockers for treatment of neuropathic pain
Tyagarajan, Sriram,Chakravarty, Prasun K.,Zhou, Bishan,Taylor, Brett,Eid, Ronsar,Fisher, Michael H.,Parsons, William H.,Wyvratt, Mathew J.,Lyons, Kathryn A.,Klatt, Tracy,Li, Xiaohua,Kumar, Sanjeev,Williams, Brande,Felix, John,Priest, Birgit T.,Brochu, Richard M.,Warren, Vivien,Smith, McHardy,Garcia, Maria,Kaczorowski, Gregory J.,Martin, William J.,Abbadie, Catherine,McGowan, Erin,Jochnowitz, Nina,Weber, Ann,Duffy, Joseph L.
scheme or table, p. 7479 - 7482 (2011/01/12)
A series of novel biphenyl pyrazole dicarboxamides were identified as potential sodium channel blockers for treatment of neuropathic pain. Compound 20 had outstanding efficacy in the Chung rat spinal nerve ligation (SNL) model of neuropathic pain.
BIARYL SUBSTITUTED PYRAZOLES AS SODIUM CHANNEL BLOCKERS
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Page 64, (2008/06/13)
Biaryl substituted pyrazole compounds are sodium channel blockers useful for the treatment of pain and other conditions. Pharmaceutical compositions comprise an effective amount of the instant compounds, either alone, or in combination with one or more th
