78440-83-2Relevant academic research and scientific papers
Synthesis of β-methoxyacrylate natural products based on box-Pd IIcatalyzed intermolecular methoxycarbonylation of alkynoles
Motodate, Satoshi,Kobayashi, Takuya,Fujii, Mikio,Mochida, Tomoyuki,Kusakabe, Taichi,Katoh, Shigeki,Akita, Hiroyuki,Kato, Keisuke
experimental part, p. 2221 - 2230 (2011/06/21)
Bis(oxazoline)-palladium(II) catalyzed carbonylation of homopropargyl alcohols afforded acyclic methoxyacrylate 2 and 6-membered lactone 3a-k in good combined yield. In the case of propargyl alcohols, 5-membered lactones 3p, 3q, 16 were obtained in moderate yields. The one-pot synthesis of kawa lactones 3a, 3r, 3s and formal synthesis of dihydroxycystothiazole A and dihydroxycystothiazole C are presented. To elucidate the stereochemistry of (+)-annularin G and (-)-annularin H, the first asymmetric syntheses of these natural products were achieved.
