78451-11-3Relevant academic research and scientific papers
THERAPEUTIC INHIBITORY COMPOUNDS
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, (2019/08/08)
Provided herein are heterocyclic derivative compounds and pharmaceutical compositions comprising said compounds that are useful for inhibiting plasma kallikrein. Furthermore, the subject compounds and compositions are useful for the treatment of diseases
SUBSTITUTED INDAZOLE COMPOUNDS AS IRAK4 INHIBITORS
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, (2016/04/26)
The present invention provides substituted indazole compound of formula (I) and pharmaceutically acceptable salts thereof, and their use to inhibit IRAK4 and/or for the treatment of diseases or disorders induced by IRAK4.
PYRROLE CARBOXYLIC ACID DERIVATIVES AS ANTIBACTERIAL AGENTS
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Paragraph 0456; 0457, (2015/04/15)
The present invention provides DNA Gyrase and/or Topo IV inhibitors of Formula (I), which can be used as antibacterial agents. Compounds disclosed herein can be used for treating or preventing conditions caused by or contributed by gram positive, gram negative and anaerobic bacteria, more particularly against, for example, Staphylococci, Streptococci, Enterococci, Haemophilus, Pseudomonus spp., Acenetobacter spp., Mvraxalla spp., Chlamydia spp., Mycoplasma spp., Legionella spp., Mycobacterium spp., Helicobacter, Clostridium spp., Bacteroides spp., Cotynebacterium, Bacillus spp., Enterobactericeae (E. coli, Klebsiella spp., Proteus spp., etc.) or any combination thereof. Also provided, are processes for preparing compounds disclosed herein, pharmaceutical compositions containing compounds disclosed herein, and methods of treating bacterial infections.
PYRROLE CARBOXYLIC ACID DERIVATIVES AS ANTIBACTERIAL AGENTS
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Page/Page column 67-68, (2010/04/03)
The present invention provides DNA Gyrase and/or Topo IV inhibitors of formula I, which can be used as antibacterial agents. Compounds disclosed herein can be used for treating or preventing conditions caused by or contributed by gram positive, gram negative and anaerobic bacteria, more particularly against, for example, Staphylococci, Streptococci, Enterococci, Haemophilus, Pseudomonus spp., Acenetobacter spp., Muraxalla spp., Chlamydia spp., Mycoplasma spp., Legionella spp., Mycobacterium spp., Helicobacter, Clostridium spp., Bacteroides spp., Cotyne bacterium, Bacillus spp., Enterobactericeae (E.coli, Klebsiella spp., Proteus spp.,etc.) or any combination thereof Also provided, are processes for preparing compounds disclosed herein, pharmaceutical compositions containing compounds disclosed herein, and methods of treating bacterial infections
2-Substituted-4-alkyl or trihaloalkyl-5-oxazolecarboxylic acids as safening agents
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, (2008/06/13)
Derivatives of 2-substituted-4-alkyl or trihaloalkyl-5-oxazolecarboxylic acid have been found to be effective in reducing herbicidal injury to crop plants caused by thiocarbamate and acetanilide herbicides, and especially in reducing herbicidal injury to rice, sorghum or wheat crops, especially rice and sorghum, caused by triallate, alachlor and butachlor herbicides.
