78455-19-3Relevant academic research and scientific papers
Palladium-catalyzed reductive coupling of phenols with anilines and amines: efficient conversion of phenolic lignin model monomers and analogues to cyclohexylamines
Chen, Zhengwang,Zeng, Huiying,Gong, Hang,Wang, Haining,Li, Chao-Jun
, p. 4174 - 4178 (2015)
Phenols, being readily available from naturally abundant lignins, are important future feedstocks for the renewable production of fuels, chemicals, and energy. Herein, a highly efficient Pd-catalyzed direct coupling of phenolic lignin model monomers and analogues with anilines to give cyclohexylamines using cheap and safe sodium formate as hydrogen donor is described. A variety of secondary and tertiary substituted cyclohexylamines can be synthesized under convenient conditions in moderate to excellent yields.
Palladium-catalyzed reductive coupling of nitroarenes with phenols leading to n-cyclohexylanilines
Liu, Kai-Jian,Zeng, Xiu-Ling,Zhang, Yong,Wang, Yi,Xiao, Xin-Sheng,Yue, Huilan,Wang, Ming,Tang, Zilong,He, Wei-Min
, p. 4637 - 4644 (2019/02/01)
A direct and efficient palladium-catalyzed reductive coupling reaction of nitroarenes with phenols has been developed. A series of Ncyclohexylaniline derivatives was easily and efficiently obtained in moderate to good yields via C-N bond formation by the
Reaction of 4-Bromo-1,2-dimethylbenzene with Various Nucleophiles via Aryne Reaction
Biehl, Edward R.,Razzuk, Aziz,Jovanovic, Misa V.,Khanapure, Subhash P.
, p. 5157 - 5160 (2007/10/02)
4-Bromo-1,2-dimethylbenzene (4a) reacts with a variety of amines, mercaptans, and nitriles under aryne-forming conditions to yield predominantly 4-substituted 1,2-dimethylbenzenes and minor quantities of 3-substituted 1,2-dimethylbenzenes.The product distributions from these reactions are heavily in favor of the 4-substituted isomer since it is formed exclusively from the symmetric 4,5-dimethylbenzyne intermediate (6) and partly from the unsymmetric 3,4-dimethylbenzyne intermediate (5).
