78460-95-4Relevant academic research and scientific papers
Quinazolines: Combined type 3 and 4 phosphodiesterase inhibitors
Charpiot, Brigitte,Brun, Jvan,Donze, Irene,Naef, Reto,Stefani, Monique,Mueller, Thomas
, p. 2891 - 2896 (1998)
A series of quinazolines has been prepared and evaluated for its ability to inhibit cyclic AMP phosphodiesterase type 3, type 4A, 4B and 4D. The most potent inhibitors showed IC50 values in the nanomolar range for type 3 and type 4 isoforms and bind with high affinity to the [3H]rolipram binding site. These quinazolines represent a new family of potent mixed PDE 3 / 4 inhibitors and are expected to have a therapeutic potential.
Synthesis and Characterization of Some Bifunctional 2B:2:1 Cryptands
Gansow, Otto A.,Kausar, A. Rashid,Triplett, Kelly B.
, p. 297 - 302 (2007/10/02)
Methods for the synthesis of aromatic substituted diaza-polyoxamacrobicyclic compounds (benzocryptands) are described.New synthetic routes to cryptand precursors are developed and improvements in cryptand synthesis discussed and employed to prepare some bifunctional cryptands.
