78462-92-7

Upstream product

• 1809-20-7 diisopropyl hydrogenphosphonate 
• 2592-73-6 1,1-dibromo-2,2-diphenylethylene 
• 20469-72-1 phenylboronic acid-d₂ 
• 3450-67-7 diethyl phenylethynylphosphonate 
• 591-50-4 iodobenzene 
• 108-86-1 bromobenzene 
• 4472-27-9 diisopropyl vinylphosphonate 
• 530-48-3 1,1-Diphenylethylene 
• 119-61-9 benzophenone 
• 13249-58-6 1-bromo-2,2-diphenylethylene 

Relevant academic research and scientific papers

Palladium-Catalyzed Addition/Cyclization of (2-Hydroxyaryl)boronic Acids with Alkynylphosphonates: Access to Phosphacoumarins

A facile palladium-catalyzed addition/cyclization of (2-hydroxyaryl)boronic acids with alkynylphosphonates has been developed, providing an effective strategy to construct a series of valuable phosphacoumarins. This methodology features excellent regioselectivity and broad substrate tolerance.

Palladium-Catalyzed Olefination of N-Tosylhydrazones as β-Diazo Phosphonate Precursors with Arylhalides

An efficient palladium-catalyzed olefination of N-tosylhydrazones as β-diazo phosphonate precursors with aryl halides has been developed. 2,2-Disubstituted vinylphosphonates bearing versatile functional groups were easily accessed in moderate to excellent

Mono and double Mizoroki-Heck reaction of aryl halides with dialkyl vinylphosphonates using a reusable palladium catalyst under aqueous medium

Operationally-simple and reusable Pd-catalyzed mono and double Mizoroki-Heck reactions of aryl halides and dialkyl vinylphosphonates using iPr2NH as a base in aqueous medium under air were developed. For aryl iodides, the reaction could be conducted at 80 °C under a low catalyst loading (0.1-1 mol%). When aryl bromides were applied, however, a greater amount of catalyst (5 mol%) and a longer reaction time at 120 °C were required. Simply changing dialkyl vinylphosphonates as the limiting reagent led to the formation of 2,2-diaryl vinylphosphonates in good to high yields. After reaction, the residual aqueous solution could be reused for both mono and double Mizoroki-Heck reactions, making the reactions greener and reducing wastage of precious metals and use of harmful organic solvents as the reaction medium.

Copper-catalyzed oxidative cross-coupling of H-phosphine oxides with alkenes in the synthesis of alkenylphosphine oxides

Abstract The first copper-catalyzed alkene oxidative cross-coupling reaction with various R2P(O)H compounds has been reported, affording a novel and efficient method for the synthesis of valuable alkenylphosphine oxides compounds with broad sub

Copper-mediated selective cross-coupling of 1,1-dibromo-1-alkenes and heteronucleophiles: Development of general routes to heterosubstituted alkynes and alkenes

Efficient and general procedures for the cross-coupling of 1,1-dibromoalkenes and N-, O-, and P-nucleophiles are reported. Fine-tuning of the reaction conditions allows for either site-selective, double, or alkynylative cross-coupling, therefore providing

Copper-mediated cross-coupling of 1,1-dibromo-1-alkenes with dialkyl phosphites: A convenient synthesis of 1-alkenylphosphonates

An efficient and stereoselective procedure for the preparation of E-1-alkenylphosphonates by copper-mediated cross-coupling between 1,1-dibromo-1-alkenes and dialkyl phosphites is reported. The reaction allows for formal substitution of both bromine atoms

Reactions of Copper(I) Halide Complexes of Trivalent Phosphorus with Vinylic Halides

The direct formation of the vinylic carbon to phosphorus bond has been accomplished via reaction of vinylic halides with copper(I) halide complexes of trialkyl phosphites.In addition, formation of varying amounts of vinylic chlorides may be observed if the reaction is performed by using vinylic bromides with copper(I) chloride complexes of trialkyl phosphites.This halogen-exchange reaction may be made synthetically useful through the employment of copper(I) chloride complexes of triaryl phosphites or phosphines.