78473-10-6

Basic information

• Product Name: 2-AMINO-3,5-DICYANOPYRIDINE
• Synonyms: 2-AMINO-3,5-DICYANOPYRIDINE;3,5-Pyridinedicarbonitrile,2-amino-(7CI,9CI);2-aMino-3,5-Pyridinedicarbonitrile;2-Aminopyridine-3,5-dicarbonitrile
• CAS NO: 78473-10-6
• Molecular Formula: C7H4N4
• Molecular Weight: 144.13
• Product Categories: NITRILE;pharmacetical
• Mol File: 78473-10-6.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 332.1 °C at 760 mmHg
• Flash Point: 154.6 °C
• Appearance: /
• Density: 1.35 g/cm³
• Vapor Pressure: 0.000149mmHg at 25°C
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• CAS DataBase Reference: 2-AMINO-3,5-DICYANOPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-3,5-DICYANOPYRIDINE(78473-10-6)
• EPA Substance Registry System: 2-AMINO-3,5-DICYANOPYRIDINE(78473-10-6)

Safety Data

• Hazardous Substances Data: 78473-10-6(Hazardous Substances Data)

Usage

Description

2-Amino-3,5-Dicyanopyridine, also known as 2-Amino-3,5-pyridinedicarbonitrile, is an organic compound with the chemical formula C7H4N4. It is a heterocyclic compound that features a pyridine ring with two cyano groups (-CN) at the 3 and 5 positions and an amino group (-NH2) at the 2 position. 2-AMINO-3,5-DICYANOPYRIDINE is known for its potential applications in the pharmaceutical and chemical industries due to its unique structure and reactivity.

Uses

Used in Pharmaceutical Industry:
2-Amino-3,5-Dicyanopyridine is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows it to be a versatile building block for the development of new drugs with potential therapeutic applications.
Used in the Development of Inhibitors of Dihydrofolate Reductase:
In the pharmaceutical industry, 2-Amino-3,5-Dicyanopyridine plays a crucial role in the development of inhibitors targeting Dihydrofolate Reductase (DHFR) enzyme. DHFR inhibitors are important in the treatment of various diseases, including cancer and microbial infections, as they disrupt the synthesis of essential biomolecules like DNA, RNA, and proteins. By incorporating 2-Amino-3,5-Dicyanopyridine into the molecular structure of DHFR inhibitors, researchers can design more potent and selective drugs to combat these diseases.

InChI:InChI=1/C7H4N4/c8-2-5-1-6(3-9)7(10)11-4-5/h1,4H,(H2,10,11)/p+1

Upstream product

• 51768-01-5 2-amino-6-chloropyridine-3,5-dicarbonitrile 
• 55244-11-6 ethyl cyanoacetimidate hydrochloride 

Downstream Products

• 172208-08-1 2-chloro-3,5-dicyanopyridine 

Relevant articles and documents

THROMBIN INHIBITORS

Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure: or a pharmaceutically acceptable salt thereof, wherein b is N Y 1 or O; c is CY 2 or N; d is CY 2; e is CY 1 or N; f is CY 1 or N; g is CY 1 or N; Y 1 is hydrogen, C 1-4 alkyl, or halogen; Y 2 is hydrogen, C 1-4 alkyl, C 3-7 cycloalkyl, halogen, NH 2, OH or C 1-4 alkoxy;A is and W, X, Z, R 3, R 4 and R 5 are defined in the specification.

Design, synthesis, computational prediction, and biological evaluation of ester soft drugs as inhibitors of dihydrofolate reductase from pneumocystis carinii

A series of lipophilic soft drugs structurally related to the nonclassical dihydrofolate reductase (DHFR) inhibitors trimetrexate and piritrexim have been designed, synthesized, and evaluated in DHFR assays, with special emphasis on the inhibition of P. c

5-methyl-5-deaza analogues of methotrexate and N10 -ethylaminopterin

It is disclosed that 5-methyl-5-deazamethotrexate and 5-methyl-5-deaza-10-ethylaminopterin are more than 10 times as potent as 5-deazamethotrexate in the L1210 cell growth inhibition test.