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78473-10-6

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78473-10-6 Usage

Description

2-Amino-3,5-Dicyanopyridine, also known as 2-Amino-3,5-pyridinedicarbonitrile, is an organic compound with the chemical formula C7H4N4. It is a heterocyclic compound that features a pyridine ring with two cyano groups (-CN) at the 3 and 5 positions and an amino group (-NH2) at the 2 position. 2-AMINO-3,5-DICYANOPYRIDINE is known for its potential applications in the pharmaceutical and chemical industries due to its unique structure and reactivity.

Uses

Used in Pharmaceutical Industry:
2-Amino-3,5-Dicyanopyridine is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows it to be a versatile building block for the development of new drugs with potential therapeutic applications.
Used in the Development of Inhibitors of Dihydrofolate Reductase:
In the pharmaceutical industry, 2-Amino-3,5-Dicyanopyridine plays a crucial role in the development of inhibitors targeting Dihydrofolate Reductase (DHFR) enzyme. DHFR inhibitors are important in the treatment of various diseases, including cancer and microbial infections, as they disrupt the synthesis of essential biomolecules like DNA, RNA, and proteins. By incorporating 2-Amino-3,5-Dicyanopyridine into the molecular structure of DHFR inhibitors, researchers can design more potent and selective drugs to combat these diseases.

Check Digit Verification of cas no

The CAS Registry Mumber 78473-10-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,8,4,7 and 3 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 78473-10:
(7*7)+(6*8)+(5*4)+(4*7)+(3*3)+(2*1)+(1*0)=156
156 % 10 = 6
So 78473-10-6 is a valid CAS Registry Number.
InChI:InChI=1/C7H4N4/c8-2-5-1-6(3-9)7(10)11-4-5/h1,4H,(H2,10,11)/p+1

78473-10-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-aminopyridine-3,5-dicarbonitrile

1.2 Other means of identification

Product number -
Other names 2-amino-pyridine-3,5-dicarbonitrile

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:78473-10-6 SDS

78473-10-6Downstream Products

78473-10-6Relevant articles and documents

THROMBIN INHIBITORS

-

, (2008/06/13)

Compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having the following structure: or a pharmaceutically acceptable salt thereof, wherein b is N Y 1 or O; c is CY 2 or N; d is CY 2; e is CY 1 or N; f is CY 1 or N; g is CY 1 or N; Y 1 is hydrogen, C 1-4 alkyl, or halogen; Y 2 is hydrogen, C 1-4 alkyl, C 3-7 cycloalkyl, halogen, NH 2, OH or C 1-4 alkoxy;A is and W, X, Z, R 3, R 4 and R 5 are defined in the specification.

Design, synthesis, computational prediction, and biological evaluation of ester soft drugs as inhibitors of dihydrofolate reductase from pneumocystis carinii

Graffner-Nordberg,Kolmodin,?qvist,Queener,Hallberg

, p. 2391 - 2402 (2007/10/03)

A series of lipophilic soft drugs structurally related to the nonclassical dihydrofolate reductase (DHFR) inhibitors trimetrexate and piritrexim have been designed, synthesized, and evaluated in DHFR assays, with special emphasis on the inhibition of P. c

5-methyl-5-deaza analogues of methotrexate and N10 -ethylaminopterin

-

, (2008/06/13)

It is disclosed that 5-methyl-5-deazamethotrexate and 5-methyl-5-deaza-10-ethylaminopterin are more than 10 times as potent as 5-deazamethotrexate in the L1210 cell growth inhibition test.

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