78476-59-2Relevant academic research and scientific papers
(Bis)urea and (Bis)thiourea inhibitors of lysine-specific demethylase 1 as epigenetic modulators
Sharma, Shiv K.,Wu, Yu,Steinbergs, Nora,Crowley, Michael L.,Hanson, Allison S.,Casero, Robert A.,Woster, Patrick M.
experimental part, p. 5197 - 5212 (2010/09/09)
The recently discovered enzyme lysine-specific demethylase 1 (LSD1) plays an important role in the epigenetic control of gene expression, and aberrant gene silencing secondary to LSD1 overexpression is thought to contribute to the development of cancer. W
Carbonyl Isocyanate Isothiocyanate
Bunnenberg, Rolf,Jochims, Johannes C.
, p. 2064 - 2074 (2007/10/02)
A synthesis of carbonyl isocyanate isothiocyanate (1) is described. 1 reacts with H2O, H2S, or HCl to give the thiadiazines 3, 6, and 14, resp.With one mol equivalent of alcohol the isothiocyanates 7 are obtained which form with further alcohol or amines compounds 8 - 10.With one mol equivalent of amine 1 gives the carbamoyl isothiocyanates 11 which form compounds 12 and 13 with further amine.Compound 1 can be chlorinated to carbonyl isocyanate isocyanide dichloride (18).Partial hydrolysis of 18 leads to carbamoyl isocyanide dichloride (19) yielding with aliphaticamines the stable carbamoyl carbodiimides 16.With alcohols 18 reacts to give the (dichloromethylene)allophanic esters 20.
