78490-09-2Relevant academic research and scientific papers
On the Reaction of α-(2-Hydroxyphenoxy)alkylketones with Dimethylsulphoxonium Methylide. A Novel Route to 2-Substituted-2,3-dihydro-2-hydroxymethyl-1,4-benzodioxins
Salimbeni, Aldo,Manghisi, Elso,Arnone, Alberto
, p. 943 - 947 (2007/10/02)
A new route to 2-substituted-2,3-dihydro-2-hydroxymethyl-1,4-benzodioxins 3 based on the reaction of α-(2-hydroxyphenoxy)alkylketones 1 with dimethylsulphoxonium methylide in dimethylsulphoxide is reported.Besides the desired compounds 3, the isomeric 2H-
THE INFLUENCE OF α-ARYL ETHERS ON THE ASYMMETRIC REDUCTION OF CARBONYLS
Samuels, William D.,Nelson, David A.,Hallen, Richard T.
, p. 3091 - 3094 (2007/10/02)
The asymmetric reduction of α-aryl ethers 1 was found to be strongly influenced by the presence of ortho substituents on the aryl ring.Groups (methoxy or hydroxy) that chelate metal cations tend to stabilize a "locked" bicyclic 4 which, intermediate when
