78491-57-3Relevant academic research and scientific papers
Silica sulfuric acid (SSA) as a highly efficient heterogeneous catalyst for persilylation of purine and pyrimidine nucleobases and other N-heterocycles using HMDS
Rad, Mohammad Navid Soltani,Khalafi-Nezhad, Ali,Divar, Masoumeh,Behrouz, Somayeh
experimental part, p. 1943 - 1954 (2010/11/16)
Purine and pyrimidine nucleobases and other N-heterocycles have been silylated with HMDS in excellent yields in the presence of a catalytic amount of silica sulfuric acid (SSA) as a heterogeneous catalyst. SSA utilizes a shorter reaction time and higher yields of silylated nucleobases. SSA is reusable for several times without a decrease in reactivity or yield of silylated adducts. Copyright
Synthesis of some novel hydrazono acyclic nucleoside analogues
Rad, Mohammad N. Soltani,Behrouz, Somayeh,Khalafi-Nezhad, Ali
experimental part, (2010/08/03)
The syntheses of novel hydrazono acyclic nucleosides similar to miconazole scaffolds are described. In this series of acyclic nucleosides, pyrimidine as well as purine and other azole derivatives replaced the imidazole function in miconazole and the ether
Reaction of 7-(2-mesyloxy-2-phenylethyl)theophylline with amines: Synthesis of 1,2,3,6-tetrahydro-6-imino-2-oxo-7H-purine derivatives
Kozai, Shigetada,Ogimoto, Kyoko,Maruyama, Tokumi
, p. 7685 - 7690 (2007/10/03)
Theophylline was converted to 7-(2-phenyl-2-methanesulfonyloxy)ethyl congener and the product was treated with ammonia or primary amines in a mixture solution of water and organic solvents. Two products were proven to be the styrene analogue and 7-(2-amino-2-phenylethyl)theophylline. The structure of the third product was elucidated as the 1,2,3,6-tetrahydro-6-imino-2-oxo-7H-purine derivatives by spectroscopic analysis including HMBC correlation and X-ray crystallography. (C) 2000 Elsevier Science Ltd.
SYNTHESIS AND PROPERTIES OF DERIVATIVES OF 7-AROYLALKYLXANTHINYL-8-THIOACETIC ACID
Garmash, S. N.,Skul'skaya, E. A.,Priimenko, B. A.,Klyuev, N. A.
, p. 807 - 811 (2007/10/02)
When 7-aroylalkyl-8-bromo-3-methyl- and -1,3-dimethylxanthines are boiled with an excess of thioglycolic acid, a reductive dehalogenation takes place, while reaction with an equimolar amount of thioglycolic acid in DMFA leads to 7-aroylalkyl-3-methyl- and -1,3-dimethylxanthinyl-8-thioacetic acids.Cyclization of the latter with acetic anhydride in the presence of anhydrous sodium acetate results in the formation of 3-aryl-1,4-dihydro-9-methyl- and -7,9-dimethylthiazinoxanthine.
Generation and Properties of N7-Xanthinium Ylides: Reactions of N7-Xanthinium Ylides with Diphenylcyclopropenone and Acetylenic Compounds
Hori, Mikio,Kataoka, Tadashi,Shimizu, Hiroshi,Imai, Eiji,Matsumoto, Yukiharu,et al.
, p. 1328 - 1332 (2007/10/02)
Xanthinium N7-ylides were generated in situ from 7-substituted 9-methylxanthinium tosylates (2) using n-BuLi in tetrahydrofuran or Et3N in MeCN.The xanthinium N7-ylides (3) generated using Et3N in MeCN reacted with diphenylcyclopropenone to give pyrone derivatives and isocaffeine in good yields.The reactions of 3a-b with dimethyl acetylenedicarboxylate or methyl propiolate (MP) afforded 5-pyrrol-1-yluracils in moderate yields.N7-Methoxycarbonylmethylide (3c) reacted with MP to give a pyrrolopteridine derivative together with a 5-pyrrol-1-yluracil derivative.Furthermore, the dihydropyrrolopurine derivative (7) , a primary 1,3-dipolar cycloaddition product, was detected by nuclear magnetic resonance measurement of the products.Keywords - xantinium N7-ylide; cycloaddition; dimethyl acetylenedicarboxylate; methyl propiolate; diphenylcyclopropenone; 5-pyrrol-1-yluracil; pyrrolopteridine; isocaffeine
