84346-92-9

Upstream product

• 70-11-1 α-bromoacetophenone 
• 58-55-9 theophylline 
• 78491-57-3 1,3-dimethyl-7-(2-oxo-2-phenylethyl)-3,7-dihydropurine-2,6-dione 
• 80-48-8 methyl p-toluene sulfonate 

Downstream Products

• 113435-39-5 (6S,7S,8S,8aR)-6-Benzoyl-1,3,9-trimethyl-2,4-dioxo-2,3,4,6,7,8,8a,9-octahydro-1H-pyrrolo[2,1-f]purine-7,8-dicarboxylic acid diphenyl ester 
• 113435-41-9 ethyl 6-benzoyl-1,3,9-trimethyl-2,4-dioxo-2,3,4,9-tetrahydro-1H-pyrrolo<2,1-f>purine-8-carboxylate 
• 113435-28-2 ethyl 6-benzoyl-1,3,9-trimethyl-2,4-dioxo-2,3,4,6,7,8,8a,9-octahydro-pyrrolo<2,1-f>purine-8-carboxylate 
• 84346-85-0 2-Benzoyl-1-(1,3-dimethyl-6-methylamino-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-1H-pyrrole-3,4-dicarboxylic acid dimethyl ester 
• 106549-51-3 8-benzoyl-6,7-bis(methoxycarbonyl)-5a,8-dihydro-5H-pyrrolo<2,1-f>purine-1(2H),3(4h)-dione 
• 84346-86-1 5-Benzoyl-1-(1,3-dimethyl-6-methylamino-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-1H-pyrrole-3-carboxylic acid methyl ester 
• 113456-58-9 (6R,8S,8aS)-6-Benzoyl-1,3,9-trimethyl-2,4-dioxo-2,3,4,6,7,8,8a,9-octahydro-1H-pyrrolo[2,1-f]purine-8-carboxylic acid methyl ester 
• 84346-81-6 C₁₆H₁₆N₄O₃ 
• 106549-49-9 N-(1,3-Dimethyl-6-methylamino-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-N-(2-oxo-2-phenyl-ethyl)-formamide 
• 113435-20-4 C₂₆H₂₃N₅O₅ 
• 78491-57-3 1,3-dimethyl-7-(2-oxo-2-phenylethyl)-3,7-dihydropurine-2,6-dione 
• 94154-76-4 (6R,7S,8S,8aS)-6-Benzoyl-1,3,9-trimethyl-2,4-dioxo-2,3,4,6,7,8,8a,9-octahydro-1H-pyrrolo[2,1-f]purine-7,8-dicarbonitrile 

Relevant academic research and scientific papers

Generation and Properties of N7-Xanthinium Ylides: Reactions of N7-Xanthinium Ylides with Diphenylcyclopropenone and Acetylenic Compounds

Xanthinium N7-ylides were generated in situ from 7-substituted 9-methylxanthinium tosylates (2) using n-BuLi in tetrahydrofuran or Et3N in MeCN.The xanthinium N7-ylides (3) generated using Et3N in MeCN reacted with diphenylcyclopropenone to give pyrone derivatives and isocaffeine in good yields.The reactions of 3a-b with dimethyl acetylenedicarboxylate or methyl propiolate (MP) afforded 5-pyrrol-1-yluracils in moderate yields.N7-Methoxycarbonylmethylide (3c) reacted with MP to give a pyrrolopteridine derivative together with a 5-pyrrol-1-yluracil derivative.Furthermore, the dihydropyrrolopurine derivative (7) , a primary 1,3-dipolar cycloaddition product, was detected by nuclear magnetic resonance measurement of the products.Keywords - xantinium N7-ylide; cycloaddition; dimethyl acetylenedicarboxylate; methyl propiolate; diphenylcyclopropenone; 5-pyrrol-1-yluracil; pyrrolopteridine; isocaffeine