78500-74-0

Upstream product

• 1120-87-2 4-bromopyridin 
• 552-89-6 2-nitro-benzaldehyde 
• 872-85-5 pyridine-4-carbaldehyde 
• 609-73-4 o-nitroiodobenzene 

Downstream Products

• 115177-76-9 (2-nitrophenyl)-(4-pyridyl)methanone 
• 115177-60-1 2-aminophenyl(4-pyridyl)-methanol 
• 78500-78-4 4-(2-aminobenzyl)pyridine 
• 78500-81-9 4-(2-azidobenzyl)pyridine 
• 115177-74-7 <1-2H>-1-(2-azidophenyl)-1-(4-pyridyl)ethane 
• 115177-73-6 C₁₃H₁₃⁽²⁾HN₂ 
• 115177-72-5 1-(2-aminophenyl)-1-(4-pyridyl)ethane 
• 115177-75-8 2-(1-Pyridin-4-yl-vinyl)-phenylamine 
• 115177-78-1 1-(2-amino-phenyl)-1-[4]pyridyl-ethanol 
• 91973-39-6 (2-Aminophenyl)-(pyridin-4-yl)methanone 

Relevant academic research and scientific papers

PYRIDINIUM DERIVATIVES AS HERBICIDES

Compounds of the formula (I) (I) wherein the substituents are as defined in claim 1, useful as a pesticides, especially as herbicides.

From in vitro to in cellulo: Structure-activity relationship of (2-nitrophenyl)methanol derivatives as inhibitors of PqsD in Pseudomonas aeruginosa

Recent studies have shown that compounds based on a (2-nitrophenyl)methanol scaffold are promising inhibitors of PqsD, a key enzyme of signal molecule biosynthesis in the cell-to-cell communication of Pseudomonas aeruginosa. The most promising molecule displayed anti-biofilm activity and a tight-binding mode of action. Herein, we report on the convenient synthesis and biochemical evaluation of a comprehensive series of (2-nitrophenyl)methanol derivatives. The in vitro potency of these inhibitors against recombinant PqsD as well as the effect of selected compounds on the production of the signal molecules HHQ and PQS in P. aeruginosa were examined. The gathered data allowed the establishment of a structure-activity relationship, which was used to design fluorescent inhibitors, and finally, led to the discovery of (2-nitrophenyl)methanol derivatives with improved in cellulo efficacy providing new perspectives towards the application of PqsD inhibitors as anti-infectives. This journal is the Partner Organisations 2014.

Intramolecular Nitrene Insertions into Aromatic and Heteroaromatic Systems. Part 7. Insertions into Electron-deficient Rings

A number of routes to o-aminotriphenylmethanes are described, where one benzene ring, or both, carry potential ester groups.The most useful synthon is shown to be the 1,3-dioxan-2-yl substituent, and using this methyl 2-aminodiphenylmethane-4'-carboxylate (18) and dimethyl 2-aminotriphenylmethane-4',4''-dicarboxylate (28) have been prepared.The azides from these, respectively (19) and (29), on thermolysis at 200 deg C gave azepinoindoles (48) and (51), the first examples of ring expansion by an arylnitrene of benzene rings with electron-withdrawing substituents.Also reported are syntheses of 3- and 4-(2-azidobenzyl)pyridines (38) and (39), and of 2-(2-azidobenzyl)thiazole (40); decomposition of these azides gave mainly polymers.