91973-39-6

Usage

Uses

Used in Pharmaceutical Research:
(2-AMINO-PHENYL)-PYRIDIN-4-YL-METHANONE is used as a key intermediate in the synthesis of various pharmaceutical compounds due to its unique structure and reactivity.
Used in Organic Synthesis:
(2-AMINO-PHENYL)-PYRIDIN-4-YL-METHANONE serves as a versatile building block in organic synthesis, enabling the creation of a wide range of chemical products.
Used in Drug Development:
(2-AMINO-PHENYL)-PYRIDIN-4-YL-METHANONE is used as a potential candidate for drug development, given its possible biological activities such as anticancer, antimicrobial, and anti-inflammatory properties.
Used in Medicinal Chemistry Studies:
It is utilized in medicinal chemistry for studying its pharmacological properties and exploring its potential as a therapeutic agent.
Used in Anticancer Applications:
(2-AMINO-PHENYL)-PYRIDIN-4-YL-METHANONE may be used as an anticancer agent, targeting various types of cancer due to its potential biological activities.
Used in Antimicrobial Applications:
(2-AMINO-PHENYL)-PYRIDIN-4-YL-METHANONE could be employed as an antimicrobial agent, helping to combat bacterial infections.
Used in Anti-inflammatory Applications:
(2-AMINO-PHENYL)-PYRIDIN-4-YL-METHANONE may also be used as an anti-inflammatory agent, potentially aiding in the treatment of inflammatory conditions.

Upstream product

• 115177-76-9 (2-nitrophenyl)-(4-pyridyl)methanone 
• 1120-87-2 4-bromopyridin 
• 29858-07-9 magnesium bromide diethyl etherate 
• 1885-29-6 anthranilic acid nitrile 
• 609-73-4 o-nitroiodobenzene 
• 62-53-3 aniline 
• 100-48-1 pyridine-4-carbonitrile 
• 280568-14-1 C₁₇H₁₈N₂O₃ 
• 1603-85-6 4-(2',4'-Dinitrobenzyl)-pyridin 
• 13671-22-2 3-nitro-4-[4]pyridylmethyl-aniline 
• 60288-89-3 4-(2-nitrobenzyl)pyridine 
• 78500-74-0 (2-nitrophenyl)(pyridin-4-yl)methanol 
• 6625-74-7 N-pivaloylaniline 
• 126971-79-7 N-{2-[hydroxy(pyridin-4-yl)methyl]-phenyl}-2,2-dimethylpropanamide 

Downstream Products

• 115177-78-1 1-(2-amino-phenyl)-1-[4]pyridyl-ethanol 
• 18631-22-6 5H-indeno[1,2-c]pyridin-5-one 
• 917460-80-1 3-(4-fluorophenyl)-4-pyridin-4-ylquinoline-2(1H)-one 
• 152665-87-7 1,3-Dihydro-5-(pyridin-4-yl)-3(R,S)-[(benzyloxycarbonyl)-amino]-2H-1,4-benzodiazepin-2-one 
• 152665-86-6 [1-(2-Cyclopentyl-2-oxo-ethyl)-2-oxo-5-pyridin-4-yl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-carbamic acid benzyl ester 
• 154064-09-2 [2-Oxo-1-(2-oxo-2-o-tolyl-ethyl)-5-pyridin-4-yl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-carbamic acid benzyl ester 
• 1224437-09-5 C₂₂H₂₅N₃O₄ 
• 827575-89-3 N-(4-{[(2-isonicotinoylphenyl)amino]sulfonyl}phenyl)acetamide 
• 115177-74-7 <1-2H>-1-(2-azidophenyl)-1-(4-pyridyl)ethane 
• 115177-73-6 C₁₃H₁₃⁽²⁾HN₂ 
• 115177-72-5 1-(2-aminophenyl)-1-(4-pyridyl)ethane 

Relevant academic research and scientific papers

PYRIDINIUM DERIVATIVES AS HERBICIDES

Compounds of the formula (I) (I) wherein the substituents are as defined in claim 1, useful as a pesticides, especially as herbicides.

Design, synthesis, crystal structures, and photophysical properties of tetraphenylethene-based quinoline derivatives

The incorporation of aggregation-induced emission (AIE) luminogens provides a molecule with enhanced fluorescent emission in the solid state. A representative AIEgen compound is tetraphenylethene (TPE). A series of new conjugates of quinolone derivatives with TPE units (1a - 1f) was synthesized and characterized. The influence on the photophysics of 1a - 1e with a variety of functional groups was investigated systematically by spectroscopic methods and simulated by density-functional theory calculations. A centrosymmetric compound donor-acceptor-donor-type compound 1f with two TPE moieties proved to be the most promising multifunctional material, it exhibited tri-colored (489–569 nm) fluorescence characteristics in tetrahydrofuran-H2O solution with a different water fraction and intense tri-colored solvatochromic (blue, green, and yellow) behaviors. These compounds could be applied as promising acid-base gas probe based on their evident color switch. Compounds 1a - 1f showed the advantage of being a potential piezochromic material.

With anti-tumor activity of triazole b the nitrogen is outstanding compound and its preparation method (by machine translation)

The invention discloses a with anti-tumor activity of triazole b the nitrogen is outstanding compound and its preparation method, which belongs to the technical field of medical synthesis. Technical point of the invention is: The invention compared with the prior art has the following advantages: the invention synthetic method is simple, novel and molecular structure can be integrated two nitrogen test paper compound and the triazole compound of the advantages of biological activity, to the breast cancer cell MCF - 7 and liver cancer cell HepG2 inhibition, is expected to be in the direction of the anti-tumor drugs further popularization and application. (by machine translation)

Azacycloheptane-o-diazepine drug molecule with antitumor activity and preparation method thereof

The invention discloses an azacycloheptane-o-diazepine drug molecule with antitumor activity and a preparation method thereof, and belongs to the technical field of medicine synthesis. According to key points of the technical scheme, the novel azacycloheptane-o-diazepine drug molecule disclosed by the invention has the following structure, wherein the structural formula is shown in the specification. The invention further discloses a preparation method of the novel azacycloheptane-o-diazepine drug molecule. The novel azacycloheptane-o-diazepine drug molecule is synthesized according to a novelmethod, the reaction process is simple and feasible in operation, the raw materials are cheap and readily available, and the novel drug molecule is high in reaction efficiency, excellent in repeatability and obvious in antitumor activity and effect.

A novel benzodiazepine three-ring compound and its preparation method and application (by machine translation)

The invention discloses a novel benzodiazepine three-ring compound and its preparation method and application, which belongs to the technical field of medical synthesis. Technical proposal of the invention points are: a novel benzodiazepine three-ring compound, has the following structure: Wherein R is O or S. The invention also discloses a novel benzodiazepine tricyclic compound of the preparation method. The invention a new method to synthesize a novel benzodiazepine three-ring compound, the reaction process is simple and easy operation, the raw material is cheap, environmental protection, higher reaction efficiency and good repeatability, has good anti-platelet aggregation activity and anti-tumor activity. (by machine translation)

4-substituted benzodiazepine 2-one compounds with anti-platelet aggregation activity and supercritical preparation method of 4-substituted benzodiazepine 2-one compounds

The invention discloses 4-substituted benzodiazepine 2-one compounds and a supercritical preparation method thereof, and belongs to the technical field of synthesis of pharmaceutical intermediates. The technical scheme is that the 4-substituted benzodiazepine 2-one compounds have the structure shown in the description, wherein R is methyl, ethyl, propyl, isopropyl, cyclopropyl or cyclohexyl. The invention further discloses the supercritical preparation method of the 4-substituted benzodiazepine 2-one compounds. The 4-substituted benzodiazepine 2-one compounds are synthesized with a novel method, the reaction process is simple and feasible to operate, the raw materials are cheap, easily available and environmentally friendly, the reaction efficiency is higher, and the repeatability is better.

2-amino substituted benzodiarizonaepine compound with antineoplastic activity and preparation method thereof

The invention discloses a 2-amino substituted benzodiarizonaepine compound with antineoplastic activity and a preparation method thereof, and belongs to the technical field of medicine synthesis. Thetechnical character of the compound is shown in the specification, wherein R is CH3, C2H5, C3H7 and phenyl. Compared with the prior art, the compound has the benefits that the synthesis method is simple, the molecular structure is novel, the reaction effect repeatability is good, the compound has inhibiting effect on both breast cancer cell MCF-7 and hepatocarcinoma cell HepG2, and is expected tobe further promoted and applied.

Bioactive 3,4,5-substituted benzodiazepine 2-one drug molecules and preparation method thereof

The invention discloses bioactive 3,4,5-substituted benzodiazepine 2-one drug molecules and a preparation method thereof and belongs to the technical field of drug synthesis. The technical scheme is characterized in that the structure of the compounds is shown in the description, wherein R1 is methyl, pyridyl, phenyl or isopropyl; R1 and R2 are selected from methyl, ethyl or phenyl independently respectively. Compared with the prior art, the compounds and the preparation method have the following beneficial effects: the synthesis method is simple, the molecular structure is novel, and the compounds have an inhibition effect on the leukemia cell line K562 and the breast cancer cell MCF-7 and are expected to be further popularized and applied.

Blue-light-emitting multifunctional triphenylamine-centered starburst quinolines: Synthesis, electrochemical and photophysical properties

A series of triphenylamine-centered starburst quinolines (1a-1g) have been synthesized by Friedlaender condensation of the 4,4′,4′′- triacetyltriphenylamine (2) and 2-aminophenyl ketones (3a-3g) in the presence of catalytic sulfuric acid and characterized well. They are thermally robust with high glass transition temperatures (above 176.4 °C) and decomposition temperatures (above 406 °C). These compounds emit blue fluorescence with λEmmax ranging from 433 to 446 nm in dilute toluene solution and 461 to 502 nm in the solid-state and have a relatively high efficiency (Φu = 0.98-0.57). 1a-1g have estimated ionization potentials (IP) of 4.54 to 6.45 eV which are significantly near or higher than those of well-known electron transport materials (ETMs), including tris(8- hydroxyquinoline)aluminium (Alq3) (IP = 5.7-5.9 eV), and previously reported oligoquinolines (IP = 5.53-5.81 eV). Quantum chemical calculations using DFT B3LYP/6-31G* showed the highest occupied molecular orbital (HOMO) of -5.05 to -4.81 eV, which is close to the work function of indium tin oxide (ITO). These results demonstrate the potential of 1a-1g as hole-transporting/light-emitting/electron-transport materials and the host-materials of a dopant for hole-injecting for applications in organic light-emitting devices.

From five- to six-membered rings: 3,4-Diarylquinolinone as lead for novel p38MAP kinase inhibitors

In this study we describe the design, synthesis, and biological evaluation of 3-(4-fluorophenyl)-4-pyridin-4-ylquinoline-2(1H)-one (5) as a new inhibitor of MAPK with a p38αMAPK IC50 of 1.8 μM. By keeping the common vicinal pyridine/4-F-phenyl