78502-81-5

Basic information

• Product Name: 5-BROMO-2-METHYL-4-PHENYL-1,3-THIAZOLE
• Synonyms: 5-BROMO-2-METHYL-4-PHENYL-1,3-THIAZOLE;5-Bromo-2-methyl-4-phenyl-1,3-thiazole 97%;5-Bromo-2-methyl-4-phenyl-1,3-thiazole97%
• CAS NO: 78502-81-5
• Molecular Formula: C₁₀H₈BrNS
• Molecular Weight: 254.15
• Mol File: 78502-81-5.mol
• Article Data: 1

Chemical Properties

• Melting Point: 68-71
• Boiling Point: 331.5 °C at 760 mmHg
• Flash Point: 154.3 °C
• Appearance: /
• Density: 1.496 g/cm³
• Vapor Pressure: 0.0003mmHg at 25°C
• Refractive Index: 1.622
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 5-BROMO-2-METHYL-4-PHENYL-1,3-THIAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-2-METHYL-4-PHENYL-1,3-THIAZOLE(78502-81-5)
• EPA Substance Registry System: 5-BROMO-2-METHYL-4-PHENYL-1,3-THIAZOLE(78502-81-5)

Safety Data

• Hazardous Substances Data: 78502-81-5(Hazardous Substances Data)

Usage

General Description

5-Bromo-2-methyl-4-phenyl-1,3-thiazole is a chemical compound with the molecular formula C10H8BrNS. It is a thiazole derivative containing a bromine atom, a methyl group, and a phenyl group. 5-BROMO-2-METHYL-4-PHENYL-1,3-THIAZOLE is used in organic synthesis and pharmaceutical research as a building block for the preparation of various thiazole-based compounds with potential biological activities. Thiazoles are known for their diverse pharmacological properties, including antimicrobial, antiviral, anti-inflammatory, and anticancer activities. The presence of the bromine atom in this compound also makes it suitable for further functionalization and modification to create new drug candidates and chemical products.

InChI:InChI=1/C10H8BrNS/c1-7-12-9(10(11)13-7)8-5-3-2-4-6-8/h2-6H,1H3

Upstream product

• 1826-16-0 2-methyl-4-phenylthiazole 

Relevant articles and documents

N-Bromosuccinimide Bromination of Substituted Methylthiazoles

Bromination of methylthiazoles with one unsubstituted position by N-bromosuccinimide may take place either at the methyl group, at the heterocyclic nucleus, or at both positions according to the nature of the second substituent.The ethoxycarbonyl group in the compounds 1a-3a directs the bromine into the side chain.So it is possible to obtain the tribromomethyl compounds 1d and 2d without bromination of the thiazole nucleus.In the phenyl-substituted methylthiazoles 4a-6a bromination takes place in the methyl group and in the heterocyclic nucleus. - The bromomethylthiazoles 1b-3b yield the vinylthiazoles 1k-3k by Wittig reaction.