1826-16-0

Basic information

• Product Name: 2-METHYL-4-PHENYL-THIAZOLE
• Synonyms: 4-Phenyl-2-methyl-1,3-thiazole;Thiazole, 2-methyl-4-phenyl-
• CAS NO: 1826-16-0
• Molecular Formula: C₁₀H₉NS
• Molecular Weight: 175.25
• Mol File: 1826-16-0.mol
• Article Data: 38

Chemical Properties

• Melting Point: 215-216℃
• Boiling Point: 284°C(lit.)
• Flash Point: 135.9 °C
• Appearance: /
• Density: 1.14 g/cm³
• Vapor Pressure: 0.00274mmHg at 25°C
• Refractive Index: 1.593
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• CAS DataBase Reference: 2-METHYL-4-PHENYL-THIAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHYL-4-PHENYL-THIAZOLE(1826-16-0)
• EPA Substance Registry System: 2-METHYL-4-PHENYL-THIAZOLE(1826-16-0)

Safety Data

• Hazardous Substances Data: 1826-16-0(Hazardous Substances Data)

Usage

Description

2-methyl-4-phenyl Thiazole is a synthetic intermediate useful for pharmaceutical synthesis.

Uses

2-methyl-4-phenyl Thiazole is a synthetic intermediate useful for pharmaceutical synthesis.[Cayman Chemical]

InChI:InChI=1/C10H9NS/c1-8-11-10(7-12-8)9-5-3-2-4-6-9/h2-7H,1H3

Upstream product

• 62-55-5 thioacetamide 
• 70-11-1 α-bromoacetophenone 
• 2462-02-4 2-mercaptoacetophenone 
• 75-05-8 acetonitrile 
• 54317-33-8 3-oxo-3-phenyl-2-(4-phenyl-thiazol-2-yl)-propionitrile 
• 532-27-4 1-chloroacetophenone 
• 339561-18-1 3-oxo-2-(4-phenyl-thiazol-2-yl)-butyric acid ethyl ester 
• 60-35-5 acetamide 
• 7257-94-5 1-phenyl-2-(p-tolylsulfonyloxy)ethanone 
• 2461-80-5 diphenacyl sulfide 
• 107-15-3 ethylenediamine 
• 131799-53-6 N-(2-Chloro-1-phenyl-1-ethylidene)isopropylamine 
• 98-86-2 acetophenone 
• 1779-49-3 Methyltriphenylphosphonium bromide 

Downstream Products

• 114380-90-4 (3-methyl-4-phenyl-thiazol-2-yl)-(4-methyl-3-phenyl-thiazol-2-yl)-methinium ; iodide 
• 93325-82-7 4-phenyl-2-styrylthiazole 
• 5968-24-1 2,3-dimethyl-4-phenylthiazolium iodide 
• 33102-81-7 2-methyl-4-(4-nitrophenyl)thiazole 
• 125509-53-7 2-methyl-4-phenylthiazole-TCNE 
• 130874-71-4 3-(2-Methyl-4-phenylthiazol-5-yl)-S-methylthiocinnamate 
• 130874-72-5 1,1-Bis(methylthio)-3-phenyl-4-(4-phenylthiazol-2-yl)butadiene 
• 129819-15-4 Isopropylidene-((Z)-1-phenyl-propenyl)-amine 
• 24840-73-1 2-methyl-4-phenyl-thiazole ethiodide 
• 125509-50-4 2-methyl-4-phenylthiazole-DDQ 
• 78502-79-1 2-(bromomethyl)-4-phenylthiazole 
• 78502-81-5 5-bromo-2-methyl-4-phenylthiazole 
• 78502-80-4 2-Dibrommethyl-4-phenylthiazol 
• 78502-82-6 5-Brom-2-brommethyl-4-phenylthiazol 

Relevant articles and documents

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Novel oxime derivative as well as preparation method and application thereof

The invention relates to a novel oxime derivative and a preparation method and application thereof, the novel oxime derivative has a structure as shown in formula (I), Q is optionally substituted phenyl, T is C1-6 alkyl substituted tetrazolyl, and A is th

Nickel/Photoredox-Catalyzed Methylation of (Hetero)aryl Chlorides Using Trimethyl Orthoformate as a Methyl Radical Source

Methylation of organohalides represents a valuable transformation, but typically requires harsh reaction conditions or reagents. We report a radical approach for the methylation of (hetero)aryl chlorides using nickel/photoredox catalysis wherein trimethyl orthoformate, a common laboratory solvent, serves as a methyl source. This method permits methylation of (hetero)aryl chlorides and acyl chlorides at an early and late stage with broad functional group compatibility. Mechanistic investigations indicate that trimethyl orthoformate serves as a source of methyl radical via β-scission from a tertiary radical generated upon chlorine-mediated hydrogen atom transfer.

Computer-Assisted Selective Optimization of Side-Activities—from Cinalukast to a PPARα Modulator

Automated computational analogue design and scoring can speed up hit-to-lead optimization and appears particularly promising in selective optimization of side-activities (SOSA) where possible analogue diversity is confined. Probing this concept, we employ