2467-02-9

Basic information

• Product Name: 2,2'-METHYLENEDIPHENOL
• Synonyms: BIS(2-HYDROXYPHENYL)METHANE;BIS(O-HYDROXYPHENYL)METHANE;2,2'-METHYLENEDIPHENOL;2,2'-DIHYDROXYDIPHENYLMETHANE;2,2’-bisphenolf;2,2’-methanediyl-di-phenol;2,2’-methylenebis-pheno;2,2’-methylenebis-phenol
• CAS NO: 2467-02-9
• Molecular Formula: C₁₃H₁₂O₂
• Molecular Weight: 200.23
• EINECS: 219-578-2
• Product Categories: Diphenylmethanes (for High-Performance Polymer Research);Functional Materials;Reagent for High-Performance Polymer Research
• Mol File: 2467-02-9.mol
• Article Data: 23

Chemical Properties

• Melting Point: 113-118 °C(lit.)
• Boiling Point: 362.5 °C at 760 mmHg
• Flash Point: 177.1 °C
• Appearance: /
• Density: 1.208 g/cm³
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
• PKA: 9.81±0.30(Predicted)
• Stability: Stable. Combustible. Incompatible with strong oxidizing agents.
• CAS DataBase Reference: 2,2'-METHYLENEDIPHENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2'-METHYLENEDIPHENOL(2467-02-9)
• EPA Substance Registry System: 2,2'-METHYLENEDIPHENOL(2467-02-9)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 2467-02-9(Hazardous Substances Data)

Usage

Chemical Properties

peach-coloured powder or chunks

Uses

2,2'-Bis(hydroxyphenyl)methane is a dihydroxydiphenyl methane and the ortho analogue of Bisphenol F (B519555). 2,2'-Bis(hydroxyphenyl)methane is a contact sensitizer found in resins and products based on phenol-formaldehyde.

InChI:InChI=1/C13H12O2/c14-12-7-3-1-5-10(12)9-11-6-2-4-8-13(11)15/h1-8,14-15H,9H2

Synthetic route

5,5'-dibromo-2,2'-dihydroxy-diphenyl-methane (78563-03-8) → Bis(2-hydroxyphenyl)methane (2467-02-9)

Conditions	Yield
With potassium hydroxide; zinc	80%
With palladium 10% on activated carbon; hydrogen In methanol at 25℃; for 5h;	62%
With aluminum nickel

formaldehyd (50-00-0) + phenol (108-95-2) → Bis(2-hydroxyphenyl)methane (2467-02-9) + 2-[(4-hydroxyphenyl)methyl]phenol (2467-03-0) + bis-(4-hydroxyphenyl)methane (620-92-8)

Conditions	Yield
Stage #1: phenol With catalyst with modified organic framework formed from chromium trioxide and phosphotungstic acid at 80℃; for 0.25h; Stage #2: formaldehyd In water at 80℃; for 0.5h; Concentration; Time; Temperature; Reagent/catalyst;	A 7.03% B 18.73% C 74.24%
Stage #1: phenol With catalyst with modified organic framework formed from ferric nitrate and phosphotungstic acid at 80℃; for 0.25h; Stage #2: formaldehyd In water at 80℃; for 4h; Concentration; Time; Temperature; Reagent/catalyst;	A 51.19% B 33.7% C 15.11%
Stage #1: phenol With catalyst with modified organic framework formed from ferric nitrate and phosphotungstic acid at 80℃; for 0.25h; Stage #2: formaldehyd In water at 80℃; for 0.5h; Concentration; Time; Temperature; Reagent/catalyst;	A 30.11% B 50.55% C 19.34%

formaldehyd (50-00-0) + phenol (108-95-2) → Bis(2-hydroxyphenyl)methane (2467-02-9)

Conditions	Yield
Stage #1: phenol With calcium silicate composite catalyst at 90℃; for 0.0833333h; Inert atmosphere; Stage #2: formaldehyd In water at 110℃; for 2h; Concentration; Reagent/catalyst; Temperature; Inert atmosphere;	56.1%

2-(1H-1,2,3-benzotriazol-1-ylmethyl)phenol (132980-32-6) + phenol (108-95-2) → Bis(2-hydroxyphenyl)methane (2467-02-9)

Conditions	Yield
With sodium t-butanolate In tert-butyl alcohol for 72h; Heating;	40%

xanthene (92-83-1) → Bis(2-hydroxyphenyl)methane (2467-02-9)

Conditions	Yield
With potassium hydroxide at 260℃;

pentan-1-ol (71-41-0) + 3-chloro-2',6-dihydroxydiphenylmethane (53007-43-5) → Bis(2-hydroxyphenyl)methane (2467-02-9)

Conditions	Yield
With sodium

pentan-1-ol (71-41-0) + 5,5'-dibromo-2,2'-dihydroxy-diphenyl-methane (78563-03-8) → Bis(2-hydroxyphenyl)methane (2467-02-9)

Conditions	Yield
With sodium

2,2'-methylenebis(4-chlorophenol) (97-23-4) → Bis(2-hydroxyphenyl)methane (2467-02-9)

Conditions	Yield
With aluminum nickel

2,2'-dihydroxybenzophenone (835-11-0) → Bis(2-hydroxyphenyl)methane (2467-02-9)

Conditions	Yield
With copper oxide-chromium oxide at 175℃; under 102971 Torr; Hydrogenation;

4,6,4'-trichloro-2,2'-methanediyl-di-phenol (5419-53-4) → Bis(2-hydroxyphenyl)methane (2467-02-9)

Conditions	Yield
With aluminum nickel

4,6-dibromo-4'-chloro-2,2'-methanediyl-di-phenol (91805-67-3) → Bis(2-hydroxyphenyl)methane (2467-02-9)

Conditions	Yield
With aluminum nickel

salicylic alcohol (90-01-7) → Bis(2-hydroxyphenyl)methane (2467-02-9) + bis-(2-hydroxybenzyl)-ether (4481-52-1)

Conditions	Yield
at 250℃; for 0.5h;

formaldehyd (50-00-0) + phenol (108-95-2) → Bis(2-hydroxyphenyl)methane (2467-02-9) + salicylaldehyde-oxime (94-67-7)

Conditions	Yield
With hydroxylamine sulfate; magnesium methanolate 1.) MeOH, toluene, reflux, 2.) 95 deg C, 30 min, 3.) H2O, 55 deg C, 1 h; Yield given. Multistep reaction. Yields of byproduct given;

phenol (108-95-2) + 2-phenyl-4H-benzo-1,3,2-dioxaborine (18885-85-3) → Bis(2-hydroxyphenyl)methane (2467-02-9) + 2-[(4-hydroxyphenyl)methyl]phenol (2467-03-0)

Conditions	Yield
With boron trifluoride diethyl etherate In 1,2-dichloro-ethane for 24h; Ambient temperature; Yield given. Yields of byproduct given;

hexachlorophene (70-30-4) → Bis(2-hydroxyphenyl)methane (2467-02-9)

Conditions	Yield
With nickel

salicylic alcohol (90-01-7) + (2-methoxyphenyl)methanol (612-16-8) + isopropyl alcohol (67-63-0) → Bis(2-hydroxyphenyl)methane (2467-02-9) + 2-[(isopropyloxy)methyl]phenol (33316-78-8) + 2-[(4-hydroxyphenyl)methyl]phenol (2467-03-0) + 2,2'-dimethoxydiphenylmethane (5819-93-2) + 2,4'-dimethoxydiphenylmethane (30567-87-4) + o-(2-propoxymethyl)anisole

Conditions	Yield
at 201.85℃; for 1h; Rate constant;	A 62 % Chromat. B 10 % Chromat. C 24 % Chromat. D n/a E n/a F 23 % Chromat.

...Expand

salicylic alcohol (90-01-7) + phenol (108-95-2) → Bis(2-hydroxyphenyl)methane (2467-02-9) + 2-[(4-hydroxyphenyl)methyl]phenol (2467-03-0) + 2,2'-dihydroxy-3-(hydroxymethyl)diphenylmethane (21243-69-6)

Conditions	Yield
at 150.85℃; for 1h; Rate constant;	A 50 % Chromat. B 31 % Chromat. C n/a

toluene (108-88-3) + phenol (108-95-2) → Bis(2-hydroxyphenyl)methane (2467-02-9) + o-Benzylphenol (28994-41-4) + ortho-cresol (95-48-7) + xylols, cresols

Conditions	Yield
zeolite CaY type at 300℃; for 0.4h; Product distribution; Mechanism; in the presence of HDPM and DHDPM;

4-bromo-phenol (106-41-2) → Bis(2-hydroxyphenyl)methane (2467-02-9)

Conditions	Yield
Multi-step reaction with 2 steps 1: aqueous H2SO4 / 60 - 70 °C 2: sodium View Scheme
Multi-step reaction with 2 steps 1: sulfuric acid / methanol / 6 h / -10 - -5 °C / Inert atmosphere 2: palladium 10% on activated carbon; hydrogen / methanol / 5 h / 25 °C View Scheme

2-(bromomethyl)-4,6-dibromophenol (4186-54-3) → Bis(2-hydroxyphenyl)methane (2467-02-9)

Conditions	Yield
Multi-step reaction with 3 steps 1: H2O; acetone 3: nickel-aluminium-alloy View Scheme

salicylic alcohol (90-01-7) → Bis(2-hydroxyphenyl)methane (2467-02-9)

Conditions	Yield
Multi-step reaction with 2 steps 1: 4-chloro-phenol; concentrated aqueous HCl / 30 °C 2: sodium View Scheme

3,5-dichloro-2-hydroxybenzyl alcohol (6641-02-7) → Bis(2-hydroxyphenyl)methane (2467-02-9)

Conditions	Yield
Multi-step reaction with 2 steps 1: POCl3 2: nickel-aluminium-alloy View Scheme

2-hydroxy-3,5-dibromobenzenemethanol (2183-54-2) → Bis(2-hydroxyphenyl)methane (2467-02-9)

Conditions	Yield
Multi-step reaction with 2 steps 2: nickel-aluminium-alloy View Scheme

4-chloro-phenol (106-48-9) → Bis(2-hydroxyphenyl)methane (2467-02-9)

Conditions	Yield
Multi-step reaction with 2 steps 1: POCl3 2: nickel-aluminium-alloy View Scheme

2,4,5-trichlorophenol (95-95-4) → Bis(2-hydroxyphenyl)methane (2467-02-9)

Conditions	Yield
Multi-step reaction with 2 steps 1: H2SO4 / methanol; H2O 2: Raney-Ni View Scheme

salicylic alcohol (90-01-7) + phenol (108-95-2) → Bis(2-hydroxyphenyl)methane (2467-02-9)

Conditions	Yield
With sulfuric acid at 100℃; for 17h;

POMM5 (13352-76-6) + phenol (108-95-2) → Bis(2-hydroxyphenyl)methane (2467-02-9) + 2-[(4-hydroxyphenyl)methyl]phenol (2467-03-0) + bis-(4-hydroxyphenyl)methane (620-92-8)

Conditions	Yield
With phosphoric acid In water at 80℃; for 4h; Overall yield = 74.8 %;

CH3-(OCH2)6-OCH3 (13352-77-7) + phenol (108-95-2) → Bis(2-hydroxyphenyl)methane (2467-02-9) + 2-[(4-hydroxyphenyl)methyl]phenol (2467-03-0) + bis-(4-hydroxyphenyl)methane (620-92-8)

Conditions	Yield
With phosphoric acid In water at 80℃; for 4h; Overall yield = 66.2 %;

CH3-(OCH2)7-OCH3 (13353-04-3) + phenol (108-95-2) → Bis(2-hydroxyphenyl)methane (2467-02-9) + 2-[(4-hydroxyphenyl)methyl]phenol (2467-03-0) + bis-(4-hydroxyphenyl)methane (620-92-8)

Conditions	Yield
With phosphoric acid In water at 80℃; for 4h; Overall yield = 60.3 %;

N,N-di(2-chloroethyl)amidophosphoric acid dichloride (127-88-8) + Bis(2-hydroxyphenyl)methane (2467-02-9) → Bis-(2-chloro-ethyl)-(6-oxo-12H-5,7-dioxa-6λ5-phospha-dibenzo[a,d]cycloocten-6-yl)-amine

Conditions	Yield
With triethylamine In ethyl acetate at 34℃; for 2h;	89%

methylphosphonic acid dichloroanhydride (676-97-1) + Bis(2-hydroxyphenyl)methane (2467-02-9) → 2-methyl-4,5;7,8-dibenzo-1,3,2λ5-dioxaphosphocine 2-oxide

Conditions	Yield
With triethylamine In diethyl ether at -6℃; for 3h;	89%

Bis(2-hydroxyphenyl)methane (2467-02-9) + trimethyl indium (3385-78-2) → [Me5In3)(2,2'-methylenediphenolate)2] (1187925-68-3)

Conditions	Yield
In methanol; diethyl ether byproducts: CH4; (N2); std. Schlenk technique; soln. of MeOH in Et2O was added to stirredsoln. of Me3In in Et2O at -76°C; warmed to room temp.; soln. of ligand in Et2O was added at -76°C; warmed to room temp.; cooled to 0°C; elem. anal.;	87%

Bis(2-hydroxyphenyl)methane (2467-02-9) + 1,1-dibromomethane (74-95-3) → 12H-dibenzo<1,3>dioxocin (256-48-4)

Conditions	Yield
With potassium carbonate; potassium iodide In N,N-dimethyl-formamide; butanone at 110℃; for 13h;	81%

Bis(2-hydroxyphenyl)methane (2467-02-9) + ethyl bromoacetate (105-36-2) → bis-(ethylphenoxy acetate) (824424-46-6)

Conditions	Yield
With caesium carbonate In acetone Heating;	75%
With caesium carbonate In acetone Heating / reflux;	75%

Bis(2-hydroxyphenyl)methane (2467-02-9) + allyl bromide (106-95-6) → bis(2-allyloxyphenyl)-methane (71355-88-9)

Conditions	Yield
With potassium carbonate In acetone for 5h; Reflux;	73%

chloro-trimethyl-silane (75-77-4) + Bis(2-hydroxyphenyl)methane (2467-02-9) → C19H28O2Si2

Conditions	Yield
Stage #1: Bis(2-hydroxyphenyl)methane With n-butyllithium In tetrahydrofuran; cyclohexane at -78 - 20℃; for 2h; Inert atmosphere; Stage #2: chloro-trimethyl-silane at 20℃; for 20h; Inert atmosphere;	71%

Bis(2-hydroxyphenyl)methane (2467-02-9) + propylphosphonic dichloride (4708-04-7) → 6-Propyl-12H-5,7-dioxa-6-phospha-dibenzo[a,d]cyclooctene 6-oxide

Conditions	Yield
With triethylamine In dichloromethane; toluene for 1h; Ambient temperature;	69%

Bis(2-hydroxyphenyl)methane (2467-02-9) + epichlorohydrin (106-89-8) → ortho,ortho-bisphenol F diglycidyl ether (54208-63-8)

Conditions	Yield
Stage #1: Bis(2-hydroxyphenyl)methane With sodium hydride In N,N-dimethyl-formamide for 0.5h; Inert atmosphere; Stage #2: epichlorohydrin In N,N-dimethyl-formamide at 20℃; for 42h; Inert atmosphere;	64%
With tetrabutylammomium bromide; potassium hydroxide	52%
With sodium hydroxide

Bis(2-hydroxyphenyl)methane (2467-02-9) + [(S,S)-bis(α-methylbenzyl)amino]phosphorous dichloride (777067-25-1) → (S,S)-(CH2(C6H4O)2)PN(CH(CH3)Ph)2

Conditions	Yield
Stage #1: Bis(2-hydroxyphenyl)methane With triethylamine In toluene at 23℃; for 0.0833333h; Inert atmosphere; Stage #2: [(S,S)-bis(α-methylbenzyl)amino]phosphorous dichloride In toluene at 23℃; for 6h; Inert atmosphere;	64%

Bis(2-hydroxyphenyl)methane (2467-02-9) + C14H21IrO4*H2O → C33H38Ir2O2

Conditions	Yield
In toluene at 100℃; for 14.5h; Inert atmosphere; Schlenk technique;	60%

Bis(2-hydroxyphenyl)methane (2467-02-9) + 1-phenylprop-2-yn-1-yl benzoate (178056-86-5) → (Z)-6-benzylidene-7,13-dihydro-6H-dibenzo[e,h][1,4]dioxonine

Conditions	Yield
With tris(dibenzylideneacetone)dipalladium(0) chloroform complex; BPPFA; caesium carbonate In tetrahydrofuran for 24h; Inert atmosphere; Schlenk technique; Reflux; stereoselective reaction;	59%

Bis(2-hydroxyphenyl)methane (2467-02-9) → 2,2'-methylenebis(4-chlorophenol) (97-23-4) + 2,2'-methylenebis(4,6-dichlorophenol) (1940-43-8)

Conditions	Yield
With sulfuryl dichloride; acetic acid	A 9% B 58%

Bis(2-hydroxyphenyl)methane (2467-02-9) → C13H11BrO2 (1009647-10-2) + 5,5'-dibromo-2,2'-dihydroxy-diphenyl-methane (78563-03-8)

Conditions	Yield
With bromine; acetic acid In dichloromethane at 20℃; for 2h;	A 41% B 53%

Bis(2-hydroxyphenyl)methane (2467-02-9) → 3-chloro-2,2'-dihydroxydiphenylmethane (133704-82-2) + 3-chloro-2',6-dihydroxydiphenylmethane (53007-43-5)

Conditions	Yield
With sulfuryl dichloride; acetic acid In dichloromethane	A 38% B 51%

tetraethylene glycol di(p-toluenesulfonate) (37860-51-8) + Bis(2-hydroxyphenyl)methane (2467-02-9) → <18>5-(2,2')diphenylmethano-24-coronand-5> (85248-34-6)

Conditions	Yield
With cesium fluoride In acetonitrile at 65℃; for 48h; under nitrogen;	49%

Bis(2-hydroxyphenyl)methane (2467-02-9) → 12H-Dibenzo<1,3,2>dioxathiocin 6-Oxide (113137-79-4)

Conditions	Yield
With pyridine; thionyl chloride In diethyl ether 1) 2h, between -2 and 0 deg C, 2) 2h, without cooling;	47%

Bis(2-hydroxyphenyl)methane (2467-02-9) + penta(ethylene glycol) bis(p-toluenesulfonate) (41024-91-3) → <21>6(2,2')Diphenylmethano.25coronand-6> (97990-42-6)

Conditions	Yield
With cesium fluoride In acetonitrile at 65℃; for 48h; under nitrogen;	45%

Bis(2-hydroxyphenyl)methane (2467-02-9) + tris(2,6-dimethylphenyl) phosphite (52830-49-6) → tris(2,6-dimethylphenoxy)phosphorane (128471-51-2)

Conditions	Yield
With chloro-diisopropyl-amine In diethyl ether at 20℃; for 10h;	42%

Bis(2-hydroxyphenyl)methane (2467-02-9) + dimethylsilicon dichloride (75-78-5) → dimethylsilane

Conditions	Yield
With triethylamine In toluene at 55℃; for 24h;	41.3%
With triethylamine

Bis(2-hydroxyphenyl)methane (2467-02-9) + n-hexan-2-one (591-78-6) → 6-butyl-6-methyl-12H-dibenzo(d,g)(1,3)dioxocin

Conditions	Yield
With indium(III) chloride for 0.5h;	40%

Bis(2-hydroxyphenyl)methane (2467-02-9) + 2,3,5,6-tetrafluoro-4-pyridinecarbonitrile (16297-07-7) → C32H20N2O4

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide at 150℃; for 0.416667h;	34%

Bis(2-hydroxyphenyl)methane (2467-02-9) → C13H10Cl4N3O2P3 + C13H10Cl4N3O2P3 + C26H21Cl3N3O4P3 + C26H20Cl2N3O4P3 + C39H32Cl2N3O6P3

Conditions	Yield
With 2,2,4,4,6,6-hexachloro-1,3,5-triaza-2,4,6-triphosphorine; sodium hydride In tetrahydrofuran; mineral oil at 20℃; for 5h; Inert atmosphere;	A 14% B 12% C 11% D 33% E 8%

Bis(2-hydroxyphenyl)methane (2467-02-9) + 1,14-dibromo-3,6,9,12-tetraoxatetradecane (57602-02-5) → <21>6(2,2')Diphenylmethano.25coronand-6> (97990-42-6)

Conditions	Yield
With potassium hydroxide In butan-1-ol for 12h; Heating;	31%

Bis(2-hydroxyphenyl)methane (2467-02-9) + ethyl acetoacetate (141-97-9) → 12H-dibenzo(d,g)(1,3)dioxocin-6-methyl-6-acetic acid ethyl ester

Conditions	Yield
With indium(III) chloride for 20h;	30%

Bis(2-hydroxyphenyl)methane (2467-02-9) + acetophenone (98-86-2) → 6-methyl-6-phenyl-12H-dibenzo(d,g)(1,3)dioxocin

Conditions	Yield
With indium(III) chloride for 0.5h;	30%

Upstream product

• 71-41-0 pentan-1-ol 
• 53007-43-5 3-chloro-2',6-dihydroxydiphenylmethane 
• 78563-03-8 5,5'-dibromo-2,2'-dihydroxy-diphenyl-methane 
• 91805-67-3 4,6-dibromo-4'-chloro-2,2'-methanediyl-di-phenol 
• 50-00-0 formaldehyd 
• 108-95-2 phenol 
• 132980-32-6 2-(1H-1,2,3-benzotriazol-1-ylmethyl)phenol 
• 90-01-7 salicylic alcohol 
• 612-16-8 (2-methoxyphenyl)methanol 
• 67-63-0 isopropyl alcohol 
• 13352-75-5 POMM₄ 
• 13353-03-2 bis-methoxymethoxy-methane 
• 628-90-0 bis(methoxymethyl)ether 
• 13352-78-8 CH₃-(OCH₂)8-OCH₃ 

Downstream Products

• 98711-13-8 bis-(2-hydroxy-3,5-bis-hydroxymethyl-phenyl)-methane 
• 71840-29-4 bis-(2-benzoyloxy-phenyl)-methane 
• 5819-93-2 2,2'-dimethoxydiphenylmethane 
• 54208-63-8 ortho,ortho-bisphenol F diglycidyl ether 
• 343229-41-4 2-[2-(4-Bromo-butoxy)-benzyl]-phenol 
• 108042-06-4 ortho,ortho-bisphenol F bis(2,3-dihydroxypropyl) ether 
• 115293-21-5 C₂₅H₂₀N₄O₂ 
• 92-83-1 xanthene 
• 95-48-7 ortho-cresol 
• 108-95-2 phenol 
• 824424-46-6 bis-(ethylphenoxy acetate) 
• 101-81-5 Diphenylmethane 
• 1009647-10-2 C₁₃H₁₁BrO₂ 
• 78563-03-8 5,5'-dibromo-2,2'-dihydroxy-diphenyl-methane 

Relevant articles and documents

Nano-silica?PVC-bonded N-ethyl sulfamic acid as a recyclable solid catalyst for the hydroxyalkylation of phenol with formaldehyde to bisphenol F

Sulfamic acid functionalized PVC-coated nano-silica (NS) catalyst (NS?PVC-EDA-SO3H) was prepared via multi-step treatment processes and characterized by FT-IR, N2 adsorption-desorption, TGA/DTG, XRD, TEM, STEM-EDS, as well as acid-base back-titration. The hydroxyalkylation of phenol with formaldehyde to bisphenol F was employed to evaluate in detail its acid catalysis performances. The results indicated that the newly constructed NS?PVC-EDA-SO3H possessed richer short mesoporous to macroporous channels and highly exposed sulfamic acids and could exhibit excellent hydroxyalkylation activity and reusability owing to fast mass transfer and reaction rates for the conversion of substrates, as well as excellent structural and chemical stabilities. This new solid acid was obviously superior to the conventional homogeneous concentrated sulfuric acid and heterogeneous sulfonated resin catalysts in catalytic activity and reusability, which could achieve a remarkable formaldehyde conversion (99.9%) and selectivity of bisphenol F (94.5%) under optimal hydroxyalkylation conditions. Furthermore, it could also be recovered easily and used repeatedly at least nine times without an obvious decrease in activity.

Hydroxyalkylation of phenol to bisphenol F over Al-pillared clay

Hydroxyalkylation of phenol to bisphenol F over the intercalation of aluminum hydroxy oligomeric into layered montmorillonite K10 was investigated. A remarkably high product yield (89.2%) and selectivity to bisphenol F (92.7%) has been achieved at a 110 °C reaction temperature and reaction time of 80 min with a Al-MMT(6) catalyst. A series of catalysts were prepared and characterized by FT-IR, XRD, BET, NH3-TPD and Py-IR. Characterization results showed that the catalytic performance of these catalysts depended on weak and moderate acidity and the textural properties (specific surface areas). The effect of the catalyst calcination temperature to this reaction was also studied. Moreover, the influences of various reaction parameters like mole ratio, catalyst concentration, reaction temperature and reaction time on the product yield and selectivity to bisphenol F were investigated. Finally, the reusability of the catalyst was studied and a plausible mechanistic pathway was proposed.

ION CHANNEL ANTAGONISTS/BLOCKERS AND USES THEREOF

Provided are ion channel antagonists/blockers and uses thereof. Specifically, it provides the compounds of formula (I) or pharmaceutically acceptable salts, stereoisomers, solvates or prodrugs, preparation method therefor and application thereof. Definition of each group in the formula can be found in the specification for details. Provided is also pharmaceutical composition useful for treatment of heart disease and other ion channel related diseases.

The invention relates to a multi-polyoxymethylene dimethyl ether as raw materials for preparing bisphenol F method

The invention relates to a method for preparing bisphenol F by adopting polyoxymethylene dimethyl ethers (PODEn; n is larger than or equal to 2 and smaller than or equal to 8) as a raw material. The method comprises the main step of carrying out a hydroxyl alkylation reaction between phenyl hydroxide and PODEn under the condition of acid catalysis, so as to obtain a target product, wherein the hydroxyl alkylation reaction can be performed in the absence of water or in the presence of water. The method has the advantages that the solubility of PODEn in phenyl hydroxide and water is high, so that a bisphenol F synthesis system serves as a homogeneous-phase system, and is conducive to heat and mass transfer; besides, PODEn has an effect of quantitatively and slowly releasing formaldehyde, so that the hydroxyl alkylation reaction is mild and easy to control, side reactions are less, such by-products as triphenol and phenolic resin are unlikely to generate, and the advantages of high yield and selectivity are achieved.